caa a22 4500 445809612 CHVBK 20180317145207.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00415-011-5902-7 doi (NATIONALLICENCE)springer-10.1007/s00415-011-5902-7 Minimally invasive stereotactic puncture and thrombolysis therapy improves long-term outcome after acute intracerebral hemorrhage [Elektronische Daten] [Houguang Zhou, Yu Zhang, Ling Liu, Yanyan Huang, Yuping Tang, Jingjing Su, Wei Hua, Xu Han, Jianzhong Xue, Qiang Dong] The purpose of this study was to judge the clinical value of minimally invasive stereotactic puncture and thrombolysis therapy (MISPTT) for acute intracerebral hemorrhage (ICH). A randomized control clinical trial was undertaken. According to the enrollment criteria, 122 acute ICH cases were analyzed, of which 64 cases received MISPTT (MISPTT group, MG) and 58 cases received conventional craniotomy (CC group, CG). The Glasgow coma scale (GCS) scores, postoperative complications (PC), and rebleeding incidences were compared. Moreover, 1year postoperation, the long-term outcomes of patients with regard to hematoma volume (HV) <50mL and HV ≥50mL were judged, respectively, by the Glasgow outcome scale (GOS), Barthel index (BI), modified Rankin Scale (mRS), and case fatality (CF). MG patients showed obvious amelioration in GCS score compared with that of CG patients. The total incidence of PC in MG decreased compared with that of CG. The incidences of rebleeding in MG and CG were 9.4 and 17.2%, respectively (P=0.243). There were no obvious differences between the CFs of MG and CG (17.2 and 25.9%, respectively, P=0.199). The GOS, BI, and mRS representing long-term outcome for both HV <50mL and HV ≥50mL in MG were ameliorated significantly greater than that in CG patients (all P<0.05). These data suggest that there are advantages with MISPTT not only in trauma and safety, but the MISPTT group had fewer complications and a trend toward improved short-term and long-term outcomes. The Author(s), 2011 Acute intracerebral hemorrhage nationallicence Minimally invasive stereotactic puncture and thrombolysis therapy nationallicence Conventional craniotomy nationallicence Urokinase nationallicence Zhou Houguang Department of Neurology, Huashan Hospital, Fudan University, 12# Middle WuLuMuQi Rd, 200040, Shanghai, China aut Zhang Yu Department of Geriatrics, Huashan Hospital, Fudan University, 12# Middle WuLuMuQi Rd, 200040, Shanghai, China aut Liu Ling Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, 305# East Zhongshan Rd, 210002, Nanjing, China aut Huang Yanyan Department of Geriatrics, Huashan Hospital, Fudan University, 12# Middle WuLuMuQi Rd, 200040, Shanghai, China aut Tang Yuping Department of Neurology, Huashan Hospital, Fudan University, 12# Middle WuLuMuQi Rd, 200040, Shanghai, China aut Su Jingjing Department of Neurology, Huashan Hospital, Fudan University, 12# Middle WuLuMuQi Rd, 200040, Shanghai, China aut Hua Wei Department of Neurosurgery, Huashan Hospital, Fudan University, 12# Middle WuLuMuQi Rd, 200040, Shanghai, China aut Han Xu Department of Neurology, Huashan Hospital, Fudan University, 12# Middle WuLuMuQi Rd, 200040, Shanghai, China aut Xue Jianzhong Department of Neurology, Affiliated ChangShu Hospital, Yangzhou University, 68# South HaiYu Rd, 215500, Changshu, China aut Dong Qiang Department of Neurology, Huashan Hospital, Fudan University, 12# Middle WuLuMuQi Rd, 200040, Shanghai, China aut Journal of Neurology Springer-Verlag 258/4(2011-04-01), 661-669 0340-5354 258:4<661 2011 258 415 https://doi.org/10.1007/s00415-011-5902-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-5902-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhou Houguang Department of Neurology, Huashan Hospital, Fudan University, 12# Middle WuLuMuQi Rd, 200040, Shanghai, China aut NATIONALLICENCE 700 1- Zhang Yu Department of Geriatrics, Huashan Hospital, Fudan University, 12# Middle WuLuMuQi Rd, 200040, Shanghai, China aut NATIONALLICENCE 700 1- Liu Ling Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, 305# East Zhongshan Rd, 210002, Nanjing, China aut NATIONALLICENCE 700 1- Huang Yanyan Department of Geriatrics, Huashan Hospital, Fudan University, 12# Middle WuLuMuQi Rd, 200040, Shanghai, China aut NATIONALLICENCE 700 1- Tang Yuping Department of Neurology, Huashan Hospital, Fudan University, 12# Middle WuLuMuQi Rd, 200040, Shanghai, China aut NATIONALLICENCE 700 1- Su Jingjing Department of Neurology, Huashan Hospital, Fudan University, 12# Middle WuLuMuQi Rd, 200040, Shanghai, China aut NATIONALLICENCE 700 1- Hua Wei Department of Neurosurgery, Huashan Hospital, Fudan University, 12# Middle WuLuMuQi Rd, 200040, Shanghai, China aut NATIONALLICENCE 700 1- Han Xu Department of Neurology, Huashan Hospital, Fudan University, 12# Middle WuLuMuQi Rd, 200040, Shanghai, China aut NATIONALLICENCE 700 1- Xue Jianzhong Department of Neurology, Affiliated ChangShu Hospital, Yangzhou University, 68# South HaiYu Rd, 215500, Changshu, China aut NATIONALLICENCE 700 1- Dong Qiang Department of Neurology, Huashan Hospital, Fudan University, 12# Middle WuLuMuQi Rd, 200040, Shanghai, China aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/4(2011-04-01), 661-669 0340-5354 258:4<661 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer