caa a22 4500 445809620 CHVBK 20180317145207.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00415-010-5817-8 doi (NATIONALLICENCE)springer-10.1007/s00415-010-5817-8 Management of punding in Parkinson's disease: an open-label prospective study [Elektronische Daten] [A. Fasano, L. Ricciardi, M. Pettorruso, A. Bentivoglio] Punding, a peculiar stereotyped behavior characterized by intense fascination with complex, excessive, non-goal-oriented, repetitive activities, is a quite rare condition complicating Parkinson's disease (PD). It is triggered by dopaminergic therapy and could have a strong impact on patient quality of life. No study has specifically investigated medical management of this condition, and only a few anecdotal reports have provided therapeutic hints. Given the suggested similarities to drug-induced dyskinesias, we have previously suggested a multistep algorithm for management of punding. We conducted a prospective open-label study on ten PD punders aimed at testing its validity. In two cases, reduction of levodopa therapy was efficacious; amantadine was effective in controlling punding in four cases; in the remaining cases, quetiapine was employed, with mild efficacy in two cases. Springer-Verlag, 2010 Amantadine nationallicence Parkinson's disease nationallicence Punding nationallicence Therapy nationallicence PD : Parkinson's disease nationallicence Fasano A. Istituto di Neurologia, Università Cattolica del Sacro Cuore Largo Agostino Gemelli, 8, 00168, Rome, Italy aut Ricciardi L. Department of Neurosciences, Psychiatry and Anaesthesiological Science, University of Messina, Messina, Italy aut Pettorruso M. Department of Psychiatry, Catholic University of Sacred Heart, Rome, Italy aut Bentivoglio A. Istituto di Neurologia, Università Cattolica del Sacro Cuore Largo Agostino Gemelli, 8, 00168, Rome, Italy aut Journal of Neurology Springer-Verlag 258/4(2011-04-01), 656-660 0340-5354 258:4<656 2011 258 415 https://doi.org/10.1007/s00415-010-5817-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5817-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fasano A. Istituto di Neurologia, Università Cattolica del Sacro Cuore Largo Agostino Gemelli, 8, 00168, Rome, Italy aut NATIONALLICENCE 700 1- Ricciardi L. Department of Neurosciences, Psychiatry and Anaesthesiological Science, University of Messina, Messina, Italy aut NATIONALLICENCE 700 1- Pettorruso M. Department of Psychiatry, Catholic University of Sacred Heart, Rome, Italy aut NATIONALLICENCE 700 1- Bentivoglio A. Istituto di Neurologia, Università Cattolica del Sacro Cuore Largo Agostino Gemelli, 8, 00168, Rome, Italy aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/4(2011-04-01), 656-660 0340-5354 258:4<656 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer