caa a22 4500 445809639 CHVBK 20180317145207.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00415-010-5789-8 doi (NATIONALLICENCE)springer-10.1007/s00415-010-5789-8 Gait variability in Parkinson's disease: an indicator of non-dopaminergic contributors to gait dysfunction? [Elektronische Daten] [Sue Lord, Katherine Baker, Alice Nieuwboer, David Burn, Lynn Rochester] Gait variability has potential utility as a predictive measure of dysfunction in Parkinson's disease (PD). Current understanding implicates non-dopaminergic pathways. This study investigated the explanatory characteristics of gait variability in PD on and off medication under single and dual task conditions. Fifty people with PD were assessed twice at home (on and off l-dopa) whilst walking under single and dual task conditions, and variability (coefficient of variation, CV) was calculated for stride time and double limb support (DLS) time. Hierarchical regression analysis was used to identify predictors. The first block of variables included age, gait speed, depression (Hospital Anxiety and Depression Scale) and fatigue (Multidimensional Fatigue Inventory), and the second block included motor severity (UPDRS III), executive function (Hayling and Brixton) and attention (Test of Everyday Attention). Motor severity predicted stride time variability and DLS time variability independent of l-dopa during single task gait. Dual task gait yielded a more complex picture. Depression made a unique contribution of 9.0% on medication and 5.0% off medication to stride time variability, and visual attention and younger age contributed to DLS variability on medication, explaining 3% and 2%, respectively. Motor severity predicted DLS variability off medication, explaining 74% of variance. Different characteristics explain the two measures of gait variability, pointing to different control mechanisms. Springer-Verlag, 2010 Parkinson's disease nationallicence Gait variability nationallicence Dopamine nationallicence Cognitive function nationallicence Cholinergic agents nationallicence Lord Sue Clinical Ageing Research Unit, Campus for Ageing and Vitality, Institute for Ageing and Health, Newcastle University, NE4 5PL, Newcastle upon Tyne, UK aut Baker Katherine Northumbria University, Newcastle, UK aut Nieuwboer Alice Katholieke Universiteit, Leuven, Belgium aut Burn David Clinical Ageing Research Unit, Campus for Ageing and Vitality, Institute for Ageing and Health, Newcastle University, NE4 5PL, Newcastle upon Tyne, UK aut Rochester Lynn Clinical Ageing Research Unit, Campus for Ageing and Vitality, Institute for Ageing and Health, Newcastle University, NE4 5PL, Newcastle upon Tyne, UK aut Journal of Neurology Springer-Verlag 258/4(2011-04-01), 566-572 0340-5354 258:4<566 2011 258 415 https://doi.org/10.1007/s00415-010-5789-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5789-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lord Sue Clinical Ageing Research Unit, Campus for Ageing and Vitality, Institute for Ageing and Health, Newcastle University, NE4 5PL, Newcastle upon Tyne, UK aut NATIONALLICENCE 700 1- Baker Katherine Northumbria University, Newcastle, UK aut NATIONALLICENCE 700 1- Nieuwboer Alice Katholieke Universiteit, Leuven, Belgium aut NATIONALLICENCE 700 1- Burn David Clinical Ageing Research Unit, Campus for Ageing and Vitality, Institute for Ageing and Health, Newcastle University, NE4 5PL, Newcastle upon Tyne, UK aut NATIONALLICENCE 700 1- Rochester Lynn Clinical Ageing Research Unit, Campus for Ageing and Vitality, Institute for Ageing and Health, Newcastle University, NE4 5PL, Newcastle upon Tyne, UK aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/4(2011-04-01), 566-572 0340-5354 258:4<566 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer