caa a22 4500 445809655 CHVBK 20180317145207.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00415-010-5795-x doi (NATIONALLICENCE)springer-10.1007/s00415-010-5795-x Basal ganglia hyperechogenicity does not distinguish between patients with primary dystonia and healthy individuals [Elektronische Daten] [Johann Hagenah, Inke König, Charlotte Kötter, Günter Seidel, Christine Klein, Norbert Brüggemann] Transcranial sonography (TCS) of the basal ganglia is a non-invasive tool to study movement disorders. Very few studies have addressed the question of whether TCS may detect specific echofeatures in patients with primary dystonia. The basal ganglia including the substantia nigra (SN) and the ventricular system were investigated by TCS in 84 primary dystonia patients and 43 neurologically healthy controls. Any hyperechogenicity of the lenticular nucleus was present in 57.5% of the patients and in 50.0% of the controls (p=0.453). While marked hyperechogenicity was more frequently present in the patients (17.8 vs. 7.9%), this difference was not significant (p=0.227). No differences in the occurrence of hyperechogenicity were detectable either in the caudate nucleus (21.6 vs. 39.5%, p=0.122) or the thalamus (4.1 vs. 0%, p=0.199). Marked hyperechogenicity of the caudate nucleus was rare in dystonia (4.1%) and absent in controls. There was no relationship between the side of basal ganglia hyperechogenicity and the clinically affected side of cervical dystonia. The area of SN echogenicity was similar in patients and controls (0.19±0.14 vs. 0.20±0.13cm2), but correlated negatively with increasing disease duration in the dystonia patients (ρ=-0.257, p=0.028). Width of the third ventricle correlated with increasing age (ρ=0.511, p=0.000) and, in patients, with disease duration (ρ=0.244, p=0.034) and severity of cervical dystonia (ρ=0.281, p=0.038). No characteristic abnormalities were found in the basal ganglia of primary dystonia patients. It remains to be explored whether this is due to a true absence of signal alterations in the basal ganglia of dystonia patients or to limitations of the current technology used. Springer-Verlag, 2010 Dystonia nationallicence Movement disorder nationallicence Substantia nigra nationallicence Lenticular nucleus nationallicence Basal ganglia nationallicence Transcranial sonography nationallicence TCS nationallicence Echogenicity nationallicence Hagenah Johann Section of Clinical and Molecular Neurogenetics, University of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany aut König Inke Institute of Medical Biometry and Statistics, University of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany aut Kötter Charlotte Department of Neurology, University of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany aut Seidel Günter Department of Neurology, University of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany aut Klein Christine Section of Clinical and Molecular Neurogenetics, University of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany aut Brüggemann Norbert Section of Clinical and Molecular Neurogenetics, University of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany aut Journal of Neurology Springer-Verlag 258/4(2011-04-01), 590-595 0340-5354 258:4<590 2011 258 415 https://doi.org/10.1007/s00415-010-5795-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5795-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hagenah Johann Section of Clinical and Molecular Neurogenetics, University of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany aut NATIONALLICENCE 700 1- König Inke Institute of Medical Biometry and Statistics, University of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany aut NATIONALLICENCE 700 1- Kötter Charlotte Department of Neurology, University of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany aut NATIONALLICENCE 700 1- Seidel Günter Department of Neurology, University of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany aut NATIONALLICENCE 700 1- Klein Christine Section of Clinical and Molecular Neurogenetics, University of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany aut NATIONALLICENCE 700 1- Brüggemann Norbert Section of Clinical and Molecular Neurogenetics, University of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/4(2011-04-01), 590-595 0340-5354 258:4<590 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer