caa a22 4500 445809744 CHVBK 20180317145207.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00415-010-5787-x doi (NATIONALLICENCE)springer-10.1007/s00415-010-5787-x Diffusion-weighted ASPECTS as an independent marker for predicting functional outcome [Elektronische Daten] [Hideaki Tei, Sinichiro Uchiyama, Toru Usui, Kuniko Ohara] Whether lesion volume on diffusion-weighted MRI imaging (DWI) can reliably predict functional outcome in acute ischemic stroke is controversial. The aim of our study was to assess whether the Alberta Stroke Program Early CT Score (ASPECTS) on DWI is useful for predicting functional outcome in patients with anterior circulation infarction with a broad range of severities. Three-hundred and fifty patients with first-ever ischemic stroke in the anterior circulation within 24h of onset were enrolled. We compared background characteristics, vital signs, laboratory data, and MRI findings between favorable (F) and unfavorable (U) outcome groups at 3months, according to the modified Rankin Scale (mRS). The F and U groups were defined as having a mRS of 0-2 and 3-6, respectively. DWI ASPECTS was scored by DWI obtained 3-24h after onset. Two-hundred and eighteen patients (62.3%) were classified into the F group and 132 patients (37.7%) into the U group. On univariate analysis, the F group patients were younger, had lower score of the National Institutes of Health Stroke Scale (NIHSS) at entry (5.7±3.3 vs. 14.2±6.0), male predominance, longer time after onset, lower rate of prior antithrombotic therapy, higher hematocrit and lower fibrinogen than the U group patients. Stroke subtype was different between the two groups, and F group patients had higher DWI ASPECTS score, lower leukoaraiosis and medial temporal atrophy score, and lower rate of early neurological deterioration (END) than the U group patients. Multiple logistic regression analysis revealed that NIHSS (p<0.001), prior antithrombotic therapy (p=0.013), ASPECTS (p=0.002), and END (p<0.001) were independent predictors of functional outcome. DWI ASPECTS can be an independent predictor for functional outcome, along with other clinical variables. Springer-Verlag, 2010 Anterior circulation infarction nationallicence Outcome assessment after stroke nationallicence Diffusion-weighted MRI nationallicence ASPECTS nationallicence Tei Hideaki Department of Neurology, Toda Central General Hospital, 1-19-3 Hon-cho, 335-0023, Toda, Saitama, Japan aut Uchiyama Sinichiro Department of Neurology, Tokyo Women's Medical University School of Medicine, Tokyo, Japan aut Usui Toru Department of Neurology, Toda Central General Hospital, 1-19-3 Hon-cho, 335-0023, Toda, Saitama, Japan aut Ohara Kuniko Department of Neurology, Toda Central General Hospital, 1-19-3 Hon-cho, 335-0023, Toda, Saitama, Japan aut Journal of Neurology Springer-Verlag 258/4(2011-04-01), 559-565 0340-5354 258:4<559 2011 258 415 https://doi.org/10.1007/s00415-010-5787-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5787-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tei Hideaki Department of Neurology, Toda Central General Hospital, 1-19-3 Hon-cho, 335-0023, Toda, Saitama, Japan aut NATIONALLICENCE 700 1- Uchiyama Sinichiro Department of Neurology, Tokyo Women's Medical University School of Medicine, Tokyo, Japan aut NATIONALLICENCE 700 1- Usui Toru Department of Neurology, Toda Central General Hospital, 1-19-3 Hon-cho, 335-0023, Toda, Saitama, Japan aut NATIONALLICENCE 700 1- Ohara Kuniko Department of Neurology, Toda Central General Hospital, 1-19-3 Hon-cho, 335-0023, Toda, Saitama, Japan aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/4(2011-04-01), 559-565 0340-5354 258:4<559 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer