caa a22 4500 445809876 CHVBK 20180317145208.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00415-011-5973-5 doi (NATIONALLICENCE)springer-10.1007/s00415-011-5973-5 Central inflammation versus peripheral regulation in multiple sclerosis [Elektronische Daten] [L. Edwards, B. Sharrack, A. Ismail, H. Tumani, C. Constantinescu] Th17 cells are a highly pro-inflammatory T-helper cell subset characterised by the expression of IL17. They have been implicated in a variety of allergic and autoimmune conditions. T-regulatory (Treg) cells, a subset of CD4 cells which express Foxp3, CD25, IL10 and TGFβ, can suppress the activity of Th17 cells. In this study, we show that the circulating levels of Th17 and Treg cells in peripheral blood are correlated; furthermore, the expression of the pro-inflammatory cytokine IL17 and the anti-inflammatory cytokine IL10 by CD4 cells are also correlated. However, we found no clear correlation between cerebrospinal fluid (CSF) IL10 and IL17 cytokine levels in MS, approaching a negative correlation at the time of relapse, and an overall negative correlation between CSF IL17 and TGFβ levels, suggesting a lack of central regulation of pro:anti-inflammatory balance in this demyelinating condition. Springer-Verlag, 2011 Th17 nationallicence Treg nationallicence Cytokines nationallicence Serum nationallicence CSF nationallicence Multiple sclerosis nationallicence Edwards L. Division of Clinical Neurology, Queen's Medical Centre, University of Nottingham, C Floor, South Block, NG7 2UH, Nottingham, United Kingdom aut Sharrack B. Sheffield Institute of Translational Neuroscience (SITraN), The University of Sheffield, 385a Glossop Road, S10 2HQ, Sheffield, United Kingdom aut Ismail A. Sheffield Institute of Translational Neuroscience (SITraN), The University of Sheffield, 385a Glossop Road, S10 2HQ, Sheffield, United Kingdom aut Tumani H. Klinik und Poliklinik für Neurologie der Universität Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany aut Constantinescu C. Division of Clinical Neurology, Queen's Medical Centre, University of Nottingham, C Floor, South Block, NG7 2UH, Nottingham, United Kingdom aut Journal of Neurology Springer-Verlag 258/8(2011-08-01), 1518-1527 0340-5354 258:8<1518 2011 258 415 https://doi.org/10.1007/s00415-011-5973-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-5973-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Edwards L. Division of Clinical Neurology, Queen's Medical Centre, University of Nottingham, C Floor, South Block, NG7 2UH, Nottingham, United Kingdom aut NATIONALLICENCE 700 1- Sharrack B. Sheffield Institute of Translational Neuroscience (SITraN), The University of Sheffield, 385a Glossop Road, S10 2HQ, Sheffield, United Kingdom aut NATIONALLICENCE 700 1- Ismail A. Sheffield Institute of Translational Neuroscience (SITraN), The University of Sheffield, 385a Glossop Road, S10 2HQ, Sheffield, United Kingdom aut NATIONALLICENCE 700 1- Tumani H. Klinik und Poliklinik für Neurologie der Universität Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany aut NATIONALLICENCE 700 1- Constantinescu C. Division of Clinical Neurology, Queen's Medical Centre, University of Nottingham, C Floor, South Block, NG7 2UH, Nottingham, United Kingdom aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/8(2011-08-01), 1518-1527 0340-5354 258:8<1518 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer