caa a22 4500 445809884 CHVBK 20180317145208.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00415-011-6061-6 doi (NATIONALLICENCE)springer-10.1007/s00415-011-6061-6 Functions of the nigrostriatal dopaminergic synapse and the use of neurotransplantation in Parkinson's disease [Elektronische Daten] [Alex Tsui, Ole Isacson] While pharmaceutical options remain the overwhelmingly accepted treatment of choice for neurological and psychiatric diseases, significant accomplishments in regenerative neuroscience research have demonstrated the potential of cellular and synaptic functional repair in future therapies. Parkinson's disease stands out as an example in which repair by dopaminergic neurons appears a viable potential therapy. This article describes the basic neurobiological underpinnings of the rationale for cell therapy for Parkinson's disease and the challenges ahead for the use of regenerative medicine in the treatment for this disease. Springer-Verlag, 2011 Parkinson's nationallicence Movement disorders nationallicence Neurotransplantation nationallicence Foetal grafting nationallicence Dyskinesias nationallicence Normal striatum nationallicence Tsui Alex University of Oxford Medical School, John Radcliffe Hospital, Oxford, UK aut Isacson Ole Harvard University Neuroregeneration Laboratories, McLean Hospital, MRC130, 115 Mill Street, Belmont, MA, USA aut Journal of Neurology Springer-Verlag 258/8(2011-08-01), 1393-1405 0340-5354 258:8<1393 2011 258 415 https://doi.org/10.1007/s00415-011-6061-6 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-6061-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tsui Alex University of Oxford Medical School, John Radcliffe Hospital, Oxford, UK aut NATIONALLICENCE 700 1- Isacson Ole Harvard University Neuroregeneration Laboratories, McLean Hospital, MRC130, 115 Mill Street, Belmont, MA, USA aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/8(2011-08-01), 1393-1405 0340-5354 258:8<1393 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer