caa a22 4500 445810017 CHVBK 20180317145208.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00415-011-5956-6 doi (NATIONALLICENCE)springer-10.1007/s00415-011-5956-6 Loss of callosal fibre integrity in healthy elderly with age-related white matter changes [Elektronische Daten] [Martin Griebe, Alex Förster, Michèle Wessa, Christina Rossmanith, Hansjörg Bäzner, Tamara Sauer, Kathrin Zohsel, Christian Blahak, Andrea King, Julia Linke, Michael Hennerici, Achim Gass, Kristina Szabo] Age-related white matter changes (ARWMC) appear to correspond to a continuum from normal functioning to clinically overt neurological syndromes. Disturbance of the structural integrity of cerebral fibre tracts—the so-called cerebral network—by ARWMC might be one explanation for this development. From 3T magnetic resonance imaging (MRI) data of 34 healthy elderly subjects (60-82years) we calculated the lesion volume of ARWMC and the area of the corpus callosum (CC). Gait, balance and cognition were assessed. We compared these findings in those with mild (n=22) and advanced (n=12) ARWMC and performed tract-based spatial statistics (TBSS) to analyze white matter structural integrity. In subjects with advanced ARWMC, TBSS showed a significant decrease of fractional anisotropy (FA) in several large tracts of the white matter including the CC; total CC, CC2 and CC5 areas were significantly smaller. Despite these morphological changes, tests of gait, balance and cognition as measured by the Mini-Mental State Examination (MMSE) were in the normal range for both groups; only the Montreal Cognitive Assessment (MoCA) detected executive and language dysfunction in those with advanced ARWMC. Loss of tissue integrity and atrophy of the CC secondary to spatially remote lesions in the peri- and paraventricular white matter in ARWMC appear to be already detectable in healthy elderly individuals. Springer-Verlag, 2011 Age-related white matter changes nationallicence Ageing nationallicence Diffusion tensor imaging nationallicence White matter lesions nationallicence Disconnection nationallicence Griebe Martin Department of Neurology, UniversitätsMedizin Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany aut Förster Alex Department of Neurology, UniversitätsMedizin Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany aut Wessa Michèle Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, 68159, Mannheim, Germany aut Rossmanith Christina Department of Neurology, UniversitätsMedizin Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany aut Bäzner Hansjörg Department of Neurology, UniversitätsMedizin Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany aut Sauer Tamara Department of Neurology, UniversitätsMedizin Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany aut Zohsel Kathrin Department of Neurology, UniversitätsMedizin Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany aut Blahak Christian Department of Neurology, UniversitätsMedizin Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany aut King Andrea Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, 68159, Mannheim, Germany aut Linke Julia Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, 68159, Mannheim, Germany aut Hennerici Michael Department of Neurology, UniversitätsMedizin Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany aut Gass Achim Department of Neurology, UniversitätsMedizin Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany aut Szabo Kristina Department of Neurology, UniversitätsMedizin Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany aut Journal of Neurology Springer-Verlag 258/8(2011-08-01), 1451-1459 0340-5354 258:8<1451 2011 258 415 https://doi.org/10.1007/s00415-011-5956-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-5956-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Griebe Martin Department of Neurology, UniversitätsMedizin Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany aut NATIONALLICENCE 700 1- Förster Alex Department of Neurology, UniversitätsMedizin Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany aut NATIONALLICENCE 700 1- Wessa Michèle Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, 68159, Mannheim, Germany aut NATIONALLICENCE 700 1- Rossmanith Christina Department of Neurology, UniversitätsMedizin Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany aut NATIONALLICENCE 700 1- Bäzner Hansjörg Department of Neurology, UniversitätsMedizin Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany aut NATIONALLICENCE 700 1- Sauer Tamara Department of Neurology, UniversitätsMedizin Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany aut NATIONALLICENCE 700 1- Zohsel Kathrin Department of Neurology, UniversitätsMedizin Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany aut NATIONALLICENCE 700 1- Blahak Christian Department of Neurology, UniversitätsMedizin Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany aut NATIONALLICENCE 700 1- King Andrea Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, 68159, Mannheim, Germany aut NATIONALLICENCE 700 1- Linke Julia Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, 68159, Mannheim, Germany aut NATIONALLICENCE 700 1- Hennerici Michael Department of Neurology, UniversitätsMedizin Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany aut NATIONALLICENCE 700 1- Gass Achim Department of Neurology, UniversitätsMedizin Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany aut NATIONALLICENCE 700 1- Szabo Kristina Department of Neurology, UniversitätsMedizin Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/8(2011-08-01), 1451-1459 0340-5354 258:8<1451 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer