caa a22 4500 445810068 CHVBK 20180317145208.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00415-011-5957-5 doi (NATIONALLICENCE)springer-10.1007/s00415-011-5957-5 The relationship between Helicobacter pylori infection and Alzheimer's disease in Japan [Elektronische Daten] [Seiji Shiota, Kazunari Murakami, Aoi Yoshiiwa, Kyoko Yamamoto, Shigeki Ohno, Akiko Kuroda, Kazuhiro Mizukami, Katsuhiro Hanada, Tadayoshi Okimoto, Masaaki Kodama, Kou Abe, Yoshio Yamaoka, Toshio Fujioka] Although two studies have indicated a possible link between Alzheimer's disease (AD) and Helicobacter pylori (H. pylori) infection, these were reported from Europe, where the prevalence of H. pylori infection is not very high. In this study, the prevalence of H. pylori infection was examined in AD patients in Japan, where there is a high prevalence of H. pylori. Consecutive patients referred to the Memory and Dementia Outpatient Clinic from August 2002 to March 2009 were studied. H. pylori infection status was determined by measuring urinary levels of anti-H. pylori antibody (RAPIRUN®). Multiple stepwise logistic regression analyses were used to examine the associations of AD with the main predictor variables. Of the 917 patients who visited the clinic, 385 were diagnosed as having AD. Ninety-seven patients did not have dementia and were considered controls. On univariate analysis, average age and the proportion of males were significantly higher in AD patients than in controls. There was no difference in the prevalence of H. pylori infection between patients with AD and controls (62.0% vs. 59.7%, p=0.67, crude odds ratio (OR), 1.10). Multiple logistic regression analysis showed that older age and male sex, but not H. pylori status, were significantly associated with AD (p<0.001, p=0.01, p=0.83, respectively). The prevalence of H. pylori infection did not differ between AD patients and controls among Japanese subjects. The high prevalence of H. pylori in controls may contribute to the discrepancy with previous reports. Springer-Verlag, 2011 Alzheimer's disease nationallicence Helicobacter pylori nationallicence Urine test nationallicence Shiota Seiji Department of General Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, 879-5593, Yufu, Oita, Japan aut Murakami Kazunari Department of General Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, 879-5593, Yufu, Oita, Japan aut Yoshiiwa Aoi Department of General Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, 879-5593, Yufu, Oita, Japan aut Yamamoto Kyoko Department of General Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, 879-5593, Yufu, Oita, Japan aut Ohno Shigeki Department of General Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, 879-5593, Yufu, Oita, Japan aut Kuroda Akiko Department of General Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, 879-5593, Yufu, Oita, Japan aut Mizukami Kazuhiro Department of General Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, 879-5593, Yufu, Oita, Japan aut Hanada Katsuhiro Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, 879-5593, Yufu, Oita, Japan aut Okimoto Tadayoshi Department of General Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, 879-5593, Yufu, Oita, Japan aut Kodama Masaaki Department of General Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, 879-5593, Yufu, Oita, Japan aut Abe Kou Department of General Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, 879-5593, Yufu, Oita, Japan aut Yamaoka Yoshio Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, 879-5593, Yufu, Oita, Japan aut Fujioka Toshio Department of General Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, 879-5593, Yufu, Oita, Japan aut Journal of Neurology Springer-Verlag 258/8(2011-08-01), 1460-1463 0340-5354 258:8<1460 2011 258 415 https://doi.org/10.1007/s00415-011-5957-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-5957-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shiota Seiji Department of General Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, 879-5593, Yufu, Oita, Japan aut NATIONALLICENCE 700 1- Murakami Kazunari Department of General Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, 879-5593, Yufu, Oita, Japan aut NATIONALLICENCE 700 1- Yoshiiwa Aoi Department of General Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, 879-5593, Yufu, Oita, Japan aut NATIONALLICENCE 700 1- Yamamoto Kyoko Department of General Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, 879-5593, Yufu, Oita, Japan aut NATIONALLICENCE 700 1- Ohno Shigeki Department of General Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, 879-5593, Yufu, Oita, Japan aut NATIONALLICENCE 700 1- Kuroda Akiko Department of General Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, 879-5593, Yufu, Oita, Japan aut NATIONALLICENCE 700 1- Mizukami Kazuhiro Department of General Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, 879-5593, Yufu, Oita, Japan aut NATIONALLICENCE 700 1- Hanada Katsuhiro Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, 879-5593, Yufu, Oita, Japan aut NATIONALLICENCE 700 1- Okimoto Tadayoshi Department of General Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, 879-5593, Yufu, Oita, Japan aut NATIONALLICENCE 700 1- Kodama Masaaki Department of General Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, 879-5593, Yufu, Oita, Japan aut NATIONALLICENCE 700 1- Abe Kou Department of General Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, 879-5593, Yufu, Oita, Japan aut NATIONALLICENCE 700 1- Yamaoka Yoshio Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, 879-5593, Yufu, Oita, Japan aut NATIONALLICENCE 700 1- Fujioka Toshio Department of General Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, 879-5593, Yufu, Oita, Japan aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/8(2011-08-01), 1460-1463 0340-5354 258:8<1460 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer