caa a22 4500 445810084 CHVBK 20180317145209.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00415-011-5960-x doi (NATIONALLICENCE)springer-10.1007/s00415-011-5960-x Serum tau protein as a marker for the diagnosis of Creutzfeldt-Jakob disease [Elektronische Daten] [Moeko Noguchi-Shinohara, Tsuyoshi Hamaguchi, Ichiro Nozaki, Kenji Sakai, Masahito Yamada] Total tau protein (t-tau) levels in cerebrospinal fluid (CSF) (CSF-tau) are markedly elevated in patients with Creutzfeldt-Jakob disease (CJD). Some CSF-tau may leak into the blood. We evaluated t-tau levels in serum (serum-tau) as a possible marker for the differential diagnosis of CJD from Alzheimer's disease (AD) and other rapidly progressive dementias (RPD). Serum- and CSF-tau levels were determined in patients with sporadic CJD (n=12), AD (n=10) and RPD but no CJD (non-CJD-RPD; n=9) who showed RPD fulfilling the World Health Organization (WHO) criteria for possible CJD at onset and had a final diagnosis other than CJD. We also analyzed serum-tau levels in healthy volunteers as a control group (n=10). Serum- as well as CSF-tau levels were significantly elevated in CJD group compared to those in AD, non-CJD-RPD and healthy control groups. Serum-tau would be a simple and useful marker to distinguish CJD from AD and non-CJD-RPD, requiring further large study to confirm this. Springer-Verlag, 2011 Creutzfeldt-Jakob disease nationallicence Alzheimer's disease nationallicence Tau protein nationallicence Cerebrospinal fluid nationallicence Serum tau protein nationallicence Noguchi-Shinohara Moeko Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, 920-8640, Kanazawa, Japan aut Hamaguchi Tsuyoshi Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, 920-8640, Kanazawa, Japan aut Nozaki Ichiro Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, 920-8640, Kanazawa, Japan aut Sakai Kenji Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, 920-8640, Kanazawa, Japan aut Yamada Masahito Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, 920-8640, Kanazawa, Japan aut Journal of Neurology Springer-Verlag 258/8(2011-08-01), 1464-1468 0340-5354 258:8<1464 2011 258 415 https://doi.org/10.1007/s00415-011-5960-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-5960-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Noguchi-Shinohara Moeko Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, 920-8640, Kanazawa, Japan aut NATIONALLICENCE 700 1- Hamaguchi Tsuyoshi Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, 920-8640, Kanazawa, Japan aut NATIONALLICENCE 700 1- Nozaki Ichiro Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, 920-8640, Kanazawa, Japan aut NATIONALLICENCE 700 1- Sakai Kenji Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, 920-8640, Kanazawa, Japan aut NATIONALLICENCE 700 1- Yamada Masahito Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, 920-8640, Kanazawa, Japan aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/8(2011-08-01), 1464-1468 0340-5354 258:8<1464 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer