caa a22 4500 445810181 CHVBK 20180317145209.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00415-010-5851-6 doi (NATIONALLICENCE)springer-10.1007/s00415-010-5851-6 Impact of fatigue on the efficacy of rehabilitation in multiple sclerosis [Elektronische Daten] [Elda Judica, Filippo Martinelli Boneschi, Daniela Ungaro, Mauro Comola, Roberto Gatti, Giancarlo Comi, Paolo Rossi] Fatigue is considered to be one of the most common and disabling symptoms among individuals with multiple sclerosis (MS). The aim of this study is to investigate if an intensive, short-term inpatient rehabilitation program is able to improve fatigue in MS, and if fatigue is able to negatively influence the clinical and functional outcome of rehabilitation in MS. One-hundred eighty six consecutively recruited MS patients underwent an intensive, short-term inpatient rehabilitation program. Sixty-four of them were selected for this study according to our inclusion criteria and compared to a control group of 22 MS patients who did not follow a rehabilitation program. We measured fatigue symptoms with the Fatigue Severity Scale (FSS) before and after rehabilitation, and classified patients into fatigued (FMS) in the case of an FSS score ≥36 and into non-fatigued MS (NFMS) in the case of an FSS <36. Expanded Disability Status Scale (EDSS) and Functional Independence Measure (FIM) were used as clinical outcome measures of the efficacy of the rehabilitation program. In our sample, an intensive, short-term rehabilitation treatment is able to determine a significant reduction of fatigue symptoms compared to untreated MS patients (p<0.0001); however, the presence of fatigue at the beginning of the rehab program seems not to have any impact on the clinical and functional outcome of rehabilitation. An intensive inpatient rehabilitation trial decreases symptom of fatigue in MS patients; furthermore fatigue seems not to modify the amelioration of disability and impairment determined by a rehabilitation program. Springer-Verlag, 2011 Fatigue nationallicence Multiple sclerosis nationallicence Rehabilitation nationallicence Outcome nationallicence Judica Elda Neurorehabilitation Unit, Department of Neurology, Institute of Experimental Neurology, Vita-Salute University, San Raffaele Scientific Institute, Milan, Italy aut Martinelli Boneschi Filippo Neurorehabilitation Unit, Department of Neurology, Institute of Experimental Neurology, Vita-Salute University, San Raffaele Scientific Institute, Milan, Italy aut Ungaro Daniela Neurorehabilitation Unit, Department of Neurology, Institute of Experimental Neurology, Vita-Salute University, San Raffaele Scientific Institute, Milan, Italy aut Comola Mauro Neurorehabilitation Unit, Department of Neurology, Institute of Experimental Neurology, Vita-Salute University, San Raffaele Scientific Institute, Milan, Italy aut Gatti Roberto Neurorehabilitation Unit, Department of Neurology, Institute of Experimental Neurology, Vita-Salute University, San Raffaele Scientific Institute, Milan, Italy aut Comi Giancarlo Neurorehabilitation Unit, Department of Neurology, Institute of Experimental Neurology, Vita-Salute University, San Raffaele Scientific Institute, Milan, Italy aut Rossi Paolo Neurorehabilitation Unit, Department of Neurology, Institute of Experimental Neurology, Vita-Salute University, San Raffaele Scientific Institute, Milan, Italy aut Journal of Neurology Springer-Verlag 258/5(2011-05-01), 835-839 0340-5354 258:5<835 2011 258 415 https://doi.org/10.1007/s00415-010-5851-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5851-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Judica Elda Neurorehabilitation Unit, Department of Neurology, Institute of Experimental Neurology, Vita-Salute University, San Raffaele Scientific Institute, Milan, Italy aut NATIONALLICENCE 700 1- Martinelli Boneschi Filippo Neurorehabilitation Unit, Department of Neurology, Institute of Experimental Neurology, Vita-Salute University, San Raffaele Scientific Institute, Milan, Italy aut NATIONALLICENCE 700 1- Ungaro Daniela Neurorehabilitation Unit, Department of Neurology, Institute of Experimental Neurology, Vita-Salute University, San Raffaele Scientific Institute, Milan, Italy aut NATIONALLICENCE 700 1- Comola Mauro Neurorehabilitation Unit, Department of Neurology, Institute of Experimental Neurology, Vita-Salute University, San Raffaele Scientific Institute, Milan, Italy aut NATIONALLICENCE 700 1- Gatti Roberto Neurorehabilitation Unit, Department of Neurology, Institute of Experimental Neurology, Vita-Salute University, San Raffaele Scientific Institute, Milan, Italy aut NATIONALLICENCE 700 1- Comi Giancarlo Neurorehabilitation Unit, Department of Neurology, Institute of Experimental Neurology, Vita-Salute University, San Raffaele Scientific Institute, Milan, Italy aut NATIONALLICENCE 700 1- Rossi Paolo Neurorehabilitation Unit, Department of Neurology, Institute of Experimental Neurology, Vita-Salute University, San Raffaele Scientific Institute, Milan, Italy aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/5(2011-05-01), 835-839 0340-5354 258:5<835 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer