caa a22 4500 445810319 CHVBK 20180317145209.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00415-010-5824-9 doi (NATIONALLICENCE)springer-10.1007/s00415-010-5824-9 Influence of CagA-positive Helicobacter pylori strains on atherosclerotic carotid disease [Elektronische Daten] [Petra Rožanković, Arijana Huzjan, Hrvoje Čupić, Ines Benčić, Silvio Bašić, Vida Demarin] Citotoxin-associated gene-A (CagA)-positive Helicobacter pylori strains have been associated with occurrence and destabilization of coronary atherosclerotic plaques. However, data on the relationship between CagA-positive H. pylori infection and carotid artery instability are lacking. Thus, the role of CagA antigen in patients with symptomatic and asymptomatic carotid atherosclerotic plaques was investigated. A total of 64 patients with advanced carotid artery stenosis, including 33 patients with symptomatic and 31 patients with asymptomatic internal carotid artery stenosis, verified by duplex ultrasound, all undergoing carotid endarterectomy, were studied. The control group consisted of 65 subjects without a history or presence of vascular diseases. Serology for H. pylori and CagA antigen was assessed in all participants. Specimens of atherosclerotic plaques obtained from all patients during carotid endarterectomy were analyzed immunohistochemically using anti-CagA monoclonal antibodies. The ultrasonographic plaque characteristics were also estimated. CagA antibody titers were significantly higher in symptomatic patients (8.8; range, 5.8-32.7) compared to asymptomatic patients (4.7; range, 2.1-8.8; P=0.005) and the control group (5.0; range 2.2-7.9; P<0.001). There was significant difference in echolucency (≥25% soft material) between the symptomatic and asymptomatic groups (P=0.034) by ultrasonographic evaluation. Positive immunoreactivity between monoclonal CagA antibodies and antigens within atherosclerotic specimens was significantly higher among symptomatic patients compared to asymptomatic patients (97.0 vs. 74.2%; P=0.009). H. pylori may play a role in the pathogenesis of the atherosclerotic process due to autoimmune mechanisms and even contribute to destabilization of carotid atherosclerotic plaques. Springer-Verlag, 2010 Symptomatic carotid artery disease nationallicence Helicobacter pylori nationallicence CagA antigen nationallicence Molecular mimicry nationallicence Rožanković Petra Department of Neurology, Clinical Hospital Dubrava, Avenija Gojka Šuška 6, 10000, Zagreb, Croatia aut Huzjan Arijana Department of Neurology, University Hospital Sestre milosrdnice, Vinogradska cesta 29, 10000, Zagreb, Croatia aut Čupić Hrvoje Department of Pathology, University Hospital Sestre milosrdnice, Vinogradska cesta 29, 10000, Zagreb, Croatia aut Benčić Ines Department of Microbiology, University Hospital Sestre milosrdnice, Vinogradska cesta 29, 10000, Zagreb, Croatia aut Bašić Silvio Department of Neurology, Clinical Hospital Dubrava, Avenija Gojka Šuška 6, 10000, Zagreb, Croatia aut Demarin Vida Department of Neurology, University Hospital Sestre milosrdnice, Vinogradska cesta 29, 10000, Zagreb, Croatia aut Journal of Neurology Springer-Verlag 258/5(2011-05-01), 753-761 0340-5354 258:5<753 2011 258 415 https://doi.org/10.1007/s00415-010-5824-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5824-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rožanković Petra Department of Neurology, Clinical Hospital Dubrava, Avenija Gojka Šuška 6, 10000, Zagreb, Croatia aut NATIONALLICENCE 700 1- Huzjan Arijana Department of Neurology, University Hospital Sestre milosrdnice, Vinogradska cesta 29, 10000, Zagreb, Croatia aut NATIONALLICENCE 700 1- Čupić Hrvoje Department of Pathology, University Hospital Sestre milosrdnice, Vinogradska cesta 29, 10000, Zagreb, Croatia aut NATIONALLICENCE 700 1- Benčić Ines Department of Microbiology, University Hospital Sestre milosrdnice, Vinogradska cesta 29, 10000, Zagreb, Croatia aut NATIONALLICENCE 700 1- Bašić Silvio Department of Neurology, Clinical Hospital Dubrava, Avenija Gojka Šuška 6, 10000, Zagreb, Croatia aut NATIONALLICENCE 700 1- Demarin Vida Department of Neurology, University Hospital Sestre milosrdnice, Vinogradska cesta 29, 10000, Zagreb, Croatia aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/5(2011-05-01), 753-761 0340-5354 258:5<753 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer