caa a22 4500 445810386 CHVBK 20180317145209.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00415-010-5842-7 doi (NATIONALLICENCE)springer-10.1007/s00415-010-5842-7 Patterns of cortical activity differ in ALS patients with limb and/or bulbar involvement depending on motor tasks [Elektronische Daten] [Katja Kollewe, Thomas Münte, Amir Samii, Reinhard Dengler, Susanne Petri, Bahram Mohammadi] Functional magnetic resonance imaging (fMRI) of hand movements in amyotrophic lateral sclerosis (ALS) has repeatedly demonstrated increased activation in cortical and subcortical areas, whereas a single study has suggested decreased rather than increased activations for tongue movements in patients with bulbar involvement. This points to differences in the pathophysiology and may correspond to the different time-course of disease for patients with and without bulbar involvement. We, therefore, compared the cortical activity during movements of the tongue and right hand using fMRI to delineate the neurofunctional correlates of bulbar versus limb symptoms in 20 ALS patients (11 with bulbar signs) and age-matched controls. During vertical tongue movements, the cortical activation pattern in ALS patients without bulbar signs did not differ from the control group. However, presence of bulbar signs caused a significant decrease of cortical activation. An increased cortical activity during the hand movement in all ALS patients was evident, regardless of site of onset and presence of bulbar signs. Thus, two different patterns of cortical activation changes suggesting fundamental differences in the neurodegenerative process and subsequent reorganisation processes exist for limb and bulbar movements. Springer-Verlag, 2010 ALS nationallicence fMRI nationallicence Plasticity nationallicence Kollewe Katja Department of Neurology and Clinical Neurophysiology, Medical School of Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Germany aut Münte Thomas Department of Neurology, University of Lübeck, Lübeck, Germany aut Samii Amir CNS-LAB, International Neuroscience Institute (INI), Hannover, Germany aut Dengler Reinhard Department of Neurology and Clinical Neurophysiology, Medical School of Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Germany aut Petri Susanne Department of Neurology and Clinical Neurophysiology, Medical School of Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Germany aut Mohammadi Bahram Department of Neurology, University of Lübeck, Lübeck, Germany aut Journal of Neurology Springer-Verlag 258/5(2011-05-01), 804-810 0340-5354 258:5<804 2011 258 415 https://doi.org/10.1007/s00415-010-5842-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5842-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kollewe Katja Department of Neurology and Clinical Neurophysiology, Medical School of Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Germany aut NATIONALLICENCE 700 1- Münte Thomas Department of Neurology, University of Lübeck, Lübeck, Germany aut NATIONALLICENCE 700 1- Samii Amir CNS-LAB, International Neuroscience Institute (INI), Hannover, Germany aut NATIONALLICENCE 700 1- Dengler Reinhard Department of Neurology and Clinical Neurophysiology, Medical School of Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Germany aut NATIONALLICENCE 700 1- Petri Susanne Department of Neurology and Clinical Neurophysiology, Medical School of Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Germany aut NATIONALLICENCE 700 1- Mohammadi Bahram Department of Neurology, University of Lübeck, Lübeck, Germany aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/5(2011-05-01), 804-810 0340-5354 258:5<804 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer