caa a22 4500 445810475 CHVBK 20180317145210.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00415-010-5840-9 doi (NATIONALLICENCE)springer-10.1007/s00415-010-5840-9 Improvement of exhausted cerebral vasoreactivity in carotid occlusion: benefit of statins? [Elektronische Daten] [Matthias Reinhard, Brigitte Guschlbauer, Manfred Olschewski, Cornelius Weiller, Andreas Hetzel] In internal carotid artery occlusion (ICAO), a spontaneous increase of cerebral vasoreactivity (CVR) may occur over time. Statins are known to increase CVR. We analyzed the influence of statin treatment and other cofactors on CVR improvement in patients with ICAO. Sixty-six patients with ICAO were reexamined after 15±6months. CVR in both middle cerebral arteries was assessed by transcranial Doppler and inhalation of 7% CO2. Pre-defined cut-off values were used to define exhausted CVR. Cofactors analyzed were: age, sex, hypertension, diabetes, statin treatment, degree of contralateral stenosis, quality of intracranial collateral flow, duration of ICAO. Mean CVR did not differ between the two studies. Twenty patients had exhausted CVR at baseline, 11 of them improved above the cut-off at follow-up (55%). Factors significantly associated with this improvement were good collateral pattern at baseline (p=0.0065) and statin treatment (p=0.0179). Odds ratios for improving CVR were 36.0 [95% CI 2.7-476.3] for good collateral flow and 20.0 [95% CI 1.7-238.6] for statin treatment. In conclusion, exhausted CVR frequently improves during the course of ICAO. Good collateral function and statin treatment are significantly associated with improving CVR. Springer-Verlag, 2010 Internal carotid artery occlusion nationallicence Cerebrovascular reactivity nationallicence Statin nationallicence Reinhard Matthias Department of Neurology, Neurocenter, University of Freiburg, Breisacher Str. 64, 79106, Freiburg, Germany aut Guschlbauer Brigitte Department of Neurology, Neurocenter, University of Freiburg, Breisacher Str. 64, 79106, Freiburg, Germany aut Olschewski Manfred Department of Medical Biometry and Statistics, University of Freiburg, Freiburg, Germany aut Weiller Cornelius Department of Neurology, Neurocenter, University of Freiburg, Breisacher Str. 64, 79106, Freiburg, Germany aut Hetzel Andreas Department of Neurology, Neurocenter, University of Freiburg, Breisacher Str. 64, 79106, Freiburg, Germany aut Journal of Neurology Springer-Verlag 258/5(2011-05-01), 791-794 0340-5354 258:5<791 2011 258 415 https://doi.org/10.1007/s00415-010-5840-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5840-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Reinhard Matthias Department of Neurology, Neurocenter, University of Freiburg, Breisacher Str. 64, 79106, Freiburg, Germany aut NATIONALLICENCE 700 1- Guschlbauer Brigitte Department of Neurology, Neurocenter, University of Freiburg, Breisacher Str. 64, 79106, Freiburg, Germany aut NATIONALLICENCE 700 1- Olschewski Manfred Department of Medical Biometry and Statistics, University of Freiburg, Freiburg, Germany aut NATIONALLICENCE 700 1- Weiller Cornelius Department of Neurology, Neurocenter, University of Freiburg, Breisacher Str. 64, 79106, Freiburg, Germany aut NATIONALLICENCE 700 1- Hetzel Andreas Department of Neurology, Neurocenter, University of Freiburg, Breisacher Str. 64, 79106, Freiburg, Germany aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/5(2011-05-01), 791-794 0340-5354 258:5<791 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer