caa a22 4500 445810602 CHVBK 20180317145210.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00415-010-5750-x doi (NATIONALLICENCE)springer-10.1007/s00415-010-5750-x Disease activity in idiopathic intracranial hypertension: a 3-month follow-up study [Elektronische Daten] [Maren Skau, Birgit Sander, Dan Milea, Rigmor Jensen] Idiopathic intracranial hypertension (IIH) is a disorder of raised intracranial pressure (ICP) in the absence of identifiable pathology. The purpose of this study was to evaluate the clinical presentation and monitor a 3-month course using frequent optical coherence tomography (OCT) evaluations, visual field testings and lumbar opening pressure measurements. A longitudinal study of 17 patients with newly diagnosed IIH and 20 healthy overweight controls were included in the study. Peripapillary retinal nerve fiber layer thickness (RNFLT) and retinal thickness (RT) measurements (Stratus OCT-3, fast RNFL 3.4 protocol), and Humphrey visual field testing were evaluated at regular intervals. Repeat lumbar puncture was performed at final visit (n=13). The diagnostic delay was 3months and initial symptoms were headache (94%), visual blurring (82%) and pulsatile tinnitus (65%). Complete clinical remission was achieved in 65%, partial in 29% and unchanged symptoms in 6%. Total average RNFLT and RT decreased significantly during the follow-up period (p<0.0001 and p<0.0001, respectively). Changes in RNFLT and RT correlated with improvements in visual field mean deviation (MD) (RNFLT: p=0.006; RT: p=0.03) and pattern standard deviation (PSD) (RNFLT: p=0.002; RT: p=0.003). In patients with weight-loss >3.5% of BMI, ICP decreased significantly (p=0.0003). In patients with weight-loss <3.5% of BMI, changes in ICP were insignificant (p=0.6). OCT combined with visual field testing may be a valuable objective tool to monitor IIH patients and the short term IIH outcome is positive. Weight-loss is the main predictor of a favorable outcome with respect to CSF pressure. Springer-Verlag, 2010 Idiopathic intracranial hypertension nationallicence Papilledema nationallicence ICP nationallicence OCT nationallicence Follow-up nationallicence Skau Maren Department of Neurology, Danish Headache Center, Glostrup Hospital, University of Copenhagen, Nordre Ringvej 57, 2600, Glostrup, Denmark aut Sander Birgit Department of Ophthalmology, Glostrup Hospital, University of Copenhagen, 2600, Glostrup, Denmark aut Milea Dan Department of Ophthalmology, Glostrup Hospital, University of Copenhagen, 2600, Glostrup, Denmark aut Jensen Rigmor Department of Neurology, Danish Headache Center, Glostrup Hospital, University of Copenhagen, Nordre Ringvej 57, 2600, Glostrup, Denmark aut Journal of Neurology Springer-Verlag 258/2(2011-02-01), 277-283 0340-5354 258:2<277 2011 258 415 https://doi.org/10.1007/s00415-010-5750-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5750-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Skau Maren Department of Neurology, Danish Headache Center, Glostrup Hospital, University of Copenhagen, Nordre Ringvej 57, 2600, Glostrup, Denmark aut NATIONALLICENCE 700 1- Sander Birgit Department of Ophthalmology, Glostrup Hospital, University of Copenhagen, 2600, Glostrup, Denmark aut NATIONALLICENCE 700 1- Milea Dan Department of Ophthalmology, Glostrup Hospital, University of Copenhagen, 2600, Glostrup, Denmark aut NATIONALLICENCE 700 1- Jensen Rigmor Department of Neurology, Danish Headache Center, Glostrup Hospital, University of Copenhagen, Nordre Ringvej 57, 2600, Glostrup, Denmark aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/2(2011-02-01), 277-283 0340-5354 258:2<277 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer