caa a22 4500 445810610 CHVBK 20180317145210.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00415-010-5756-4 doi (NATIONALLICENCE)springer-10.1007/s00415-010-5756-4 An early rise in body temperature is related to unfavorable outcome after stroke: data from the PAIS study [Elektronische Daten] [Heleen den Hertog, H. van der Worp, H. van Gemert, Ale Algra, L. Kappelle, Jan van Gijn, Peter Koudstaal, Diederik Dippel] Subfebrile temperature or fever is present in about a third of patients on the first day after stroke onset and is associated with poor outcome. However, the temporal profile of this association is not well established. We aimed to assess the relationship between body temperature on admission as well as the change in body temperature from admission to 24h thereafter and functional outcome and death. We analyzed data of 1,332 patients admitted within 12h of stroke onset. The relation between body temperature on admission or the change in body temperature from admission to 24h thereafter (adjusted for body temperature on admission) on the one hand and unfavorable outcome (death, or a modified Rankin Scale score>2) at 3months on the other were expressed as odds ratio per 1.0°C increase in body temperature. Adjustments for potential confounders were made with a multiple logistic regression model. No relation was found between admission body temperature and poor outcome (aOR 1.06; 95% CI 0.85-1.32) and death (aOR 1.23; 95% CI 0.95-1.60). In contrast, increased body temperature in the first 24h after stroke onset was associated with poor outcome (aOR 1.30; 95% CI 1.05-1.63) and death (aOR 1.51; 95% CI 1.15-1.98). An early rise in body temperature rather than high body temperature on admission is a risk factor for unfavorable outcome in patients with acute stroke. The Author(s), 2010 Stroke nationallicence Body temperature nationallicence Clinical outcome nationallicence den Hertog Heleen Department of Neurology, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA, Rotterdam, The Netherlands aut van der Worp H. Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands aut van Gemert H. Department of Neurology, Meander Medical Center, Amersfoort, The Netherlands aut Algra Ale Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands aut Kappelle L. Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands aut van Gijn Jan Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands aut Koudstaal Peter Department of Neurology, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA, Rotterdam, The Netherlands aut Dippel Diederik Department of Neurology, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA, Rotterdam, The Netherlands aut Journal of Neurology Springer-Verlag 258/2(2011-02-01), 302-307 0340-5354 258:2<302 2011 258 415 https://doi.org/10.1007/s00415-010-5756-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5756-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- den Hertog Heleen Department of Neurology, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- van der Worp H. Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands aut NATIONALLICENCE 700 1- van Gemert H. Department of Neurology, Meander Medical Center, Amersfoort, The Netherlands aut NATIONALLICENCE 700 1- Algra Ale Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands aut NATIONALLICENCE 700 1- Kappelle L. Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands aut NATIONALLICENCE 700 1- van Gijn Jan Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands aut NATIONALLICENCE 700 1- Koudstaal Peter Department of Neurology, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Dippel Diederik Department of Neurology, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA, Rotterdam, The Netherlands aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/2(2011-02-01), 302-307 0340-5354 258:2<302 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer