caa a22 4500 445810661 CHVBK 20180317145210.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00415-010-5742-x doi (NATIONALLICENCE)springer-10.1007/s00415-010-5742-x Is central fatigue in multiple sclerosis a disorder of movement preparation? [Elektronische Daten] [Francesca Morgante, Vincenzo Dattola, Domenica Crupi, Margherita Russo, Vincenzo Rizzo, Maria Ghilardi, Carmen Terranova, Paolo Girlanda, Angelo Quartarone] We tested the hypothesis that fatigue in MS is related to a dysfunction in cortical areas involved in movement preparation. Thirty-three patients with clinically definite MS (16 with fatigue MS-F, 17 without fatigue MS-NF) and a relapsing-remitting course, matched for disease severity and duration, disability scores and level of depression were enrolled. They underwent a combined assessment with magnetic resonance imaging (MRI) and transcranial magnetic stimulation (TMS) and, for the electrophysiological study, were compared with 12 healthy controls. MRI was used to assess regional and total lesion-load volume (LL) on T1- and T2-weighted sequences and total brain volume on T1-weighted sequences. With TMS we tested central motor conduction time, short intracortical inhibition (SICI) and facilitation (ICF), pre-movement facilitation related to a simple reaction time paradigm and the effect of short trains of 5-Hz repetitive TMS (rTMS). No significant differences were found in total and regional LL between MS-F and MS-NF, except for a significant increase in frontal lobe LL in MS-F. Neurophysiological assessment did not disclose any difference of SICI and ICF among the three groups. The significant increase of MEP size produced by 5Hz rTMS in controls was absent in both MS-NF and MS-F. MS-F lacked pre-movement facilitation compared with MS-NF and controls. The lack of pre-movement facilitation and the increased frontal lobe lesion load were significantly correlated to the FSS score, suggesting that central fatigue in MS is probably due to a dysfunction of cortical motor areas involved in movement preparation. Springer-Verlag, 2010 Multiple sclerosis nationallicence Fatigue nationallicence Frontal lobe nationallicence Transcranial magnetic stimulation nationallicence Morgante Francesca Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina, Via Consolare Valeria 1, 98125, Messina, Italy aut Dattola Vincenzo Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina, Via Consolare Valeria 1, 98125, Messina, Italy aut Crupi Domenica Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina, Via Consolare Valeria 1, 98125, Messina, Italy aut Russo Margherita Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina, Via Consolare Valeria 1, 98125, Messina, Italy aut Rizzo Vincenzo Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina, Via Consolare Valeria 1, 98125, Messina, Italy aut Ghilardi Maria Department of Physiology and Pharmacology, CUNY Medical School, New York, NY, USA aut Terranova Carmen Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina, Via Consolare Valeria 1, 98125, Messina, Italy aut Girlanda Paolo Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina, Via Consolare Valeria 1, 98125, Messina, Italy aut Quartarone Angelo Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina, Via Consolare Valeria 1, 98125, Messina, Italy aut Journal of Neurology Springer-Verlag 258/2(2011-02-01), 263-272 0340-5354 258:2<263 2011 258 415 https://doi.org/10.1007/s00415-010-5742-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5742-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Morgante Francesca Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina, Via Consolare Valeria 1, 98125, Messina, Italy aut NATIONALLICENCE 700 1- Dattola Vincenzo Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina, Via Consolare Valeria 1, 98125, Messina, Italy aut NATIONALLICENCE 700 1- Crupi Domenica Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina, Via Consolare Valeria 1, 98125, Messina, Italy aut NATIONALLICENCE 700 1- Russo Margherita Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina, Via Consolare Valeria 1, 98125, Messina, Italy aut NATIONALLICENCE 700 1- Rizzo Vincenzo Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina, Via Consolare Valeria 1, 98125, Messina, Italy aut NATIONALLICENCE 700 1- Ghilardi Maria Department of Physiology and Pharmacology, CUNY Medical School, New York, NY, USA aut NATIONALLICENCE 700 1- Terranova Carmen Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina, Via Consolare Valeria 1, 98125, Messina, Italy aut NATIONALLICENCE 700 1- Girlanda Paolo Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina, Via Consolare Valeria 1, 98125, Messina, Italy aut NATIONALLICENCE 700 1- Quartarone Angelo Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina, Via Consolare Valeria 1, 98125, Messina, Italy aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/2(2011-02-01), 263-272 0340-5354 258:2<263 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer