caa a22 4500 44581067X CHVBK 20180317145211.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00415-010-5796-9 doi (NATIONALLICENCE)springer-10.1007/s00415-010-5796-9 Gene therapy: a viable therapeutic strategy for Parkinson's disease? [Elektronische Daten] [Alexander Berry, Thomas Foltynie] Gene therapy represents a potentially useful additional technique to ameliorate the motor symptoms of Parkinson's disease (PD), and the motor complications of its treatment. The neurodegenerative process itself, as well as the non-motor symptoms of PD, both remain less amenable to most of the current gene therapy approaches. This review presents an overview of the four gene therapies in phase I/II clinical trials, outlines some of the challenges they face, and proposes additional alternative strategies that might improve the clinical prospects of gene therapy for PD. In so doing, we hope to highlight the issue of the current absence of effective treatment for non-motor symptoms of PD and the potential of further candidate targets for gene therapy intervention that might improve upon this, for both specific individuals with genetic forms of PD as well as "sporadic” PD patients. Springer-Verlag, 2010 Parkinson's disease nationallicence Gene therapy nationallicence Basal ganglia nationallicence Non-motor nationallicence Berry Alexander Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, WC1N 3BG, London, UK aut Foltynie Thomas Sobell Department of Motor Neuroscience, UCL Institute of Neurology, Queen Square, WC1N 3BG, London, UK aut Journal of Neurology Springer-Verlag 258/2(2011-02-01), 179-188 0340-5354 258:2<179 2011 258 415 https://doi.org/10.1007/s00415-010-5796-9 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5796-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Berry Alexander Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, WC1N 3BG, London, UK aut NATIONALLICENCE 700 1- Foltynie Thomas Sobell Department of Motor Neuroscience, UCL Institute of Neurology, Queen Square, WC1N 3BG, London, UK aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/2(2011-02-01), 179-188 0340-5354 258:2<179 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer