caa a22 4500 445810696 CHVBK 20180317145211.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00415-010-5712-3 doi (NATIONALLICENCE)springer-10.1007/s00415-010-5712-3 Cold paresis in multifocal motor neuropathy [Elektronische Daten] [Dirk Straver, Jan-Thies van Asseldonk, Nicolette Notermans, John Wokke, Leonard van den Berg, Hessel Franssen] Increased weakness during cold (cold paresis) was reported in single cases of multifocal motor neuropathy (MMN). This was unexpected because demyelination is a feature of MMN and symptoms of demyelination improve, rather than worsen, in cold. It was hypothesized that cold paresis in MMN does not reflect demyelination only, but may indicate the existence of inflammatory nerve lesions with permanently depolarized axons that only just conduct at normal temperature, but fail at lower temperatures. We investigated symptoms of cold paresis in 50 MMN patients, 48 chronic inflammatory demyelinating polyneuropathy (CIDP) patients, 35 progressive spinal muscular atrophy (PSMA) patients, and 25 chronic idiopathic axonal polyneuropathy patients. We also investigated symptoms of increased weakness during warmth (heat paresis). Cold paresis was reported more often than heat paresis. Cold paresis was most frequently reported in MMN. Multivariate analysis indicated that MMN patients had a 4- to 6-fold higher risk of reporting cold paresis than CIDP or PSMA patients. Because cold paresis is not consistent with demyelination, the lesions in MMN may involve other mechanisms than demyelination only. In conclusion, symptoms of cold paresis are common in peripheral nervous system disorders, particularly in MMN. This supports the above-described hypothesis. The Author(s), 2010 Multifocal motor neuropathy nationallicence Chronic inflammatory demyelinating polyneuropathy nationallicence Chronic idiopathic axonal polyneuropathy nationallicence Progressive spinal muscular atrophy nationallicence Cold paresis nationallicence CB : Conduction block nationallicence CIAP : Chronic idiopathic axonal polyneuropathy nationallicence CIDP : Chronic inflammatory demyelinating polyneuropathy nationallicence MMN : Multifocal motor neuropathy nationallicence PSMA : Progressive spinal muscular atrophy nationallicence Straver Dirk Neuromuscular Disease Group, Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands aut van Asseldonk Jan-Thies Neuromuscular Disease Group, Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands aut Notermans Nicolette Neuromuscular Disease Group, Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands aut Wokke John Neuromuscular Disease Group, Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands aut van den Berg Leonard Neuromuscular Disease Group, Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands aut Franssen Hessel Neuromuscular Disease Group, Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands aut Journal of Neurology Springer-Verlag 258/2(2011-02-01), 212-217 0340-5354 258:2<212 2011 258 415 https://doi.org/10.1007/s00415-010-5712-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5712-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Straver Dirk Neuromuscular Disease Group, Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands aut NATIONALLICENCE 700 1- van Asseldonk Jan-Thies Neuromuscular Disease Group, Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands aut NATIONALLICENCE 700 1- Notermans Nicolette Neuromuscular Disease Group, Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands aut NATIONALLICENCE 700 1- Wokke John Neuromuscular Disease Group, Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands aut NATIONALLICENCE 700 1- van den Berg Leonard Neuromuscular Disease Group, Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands aut NATIONALLICENCE 700 1- Franssen Hessel Neuromuscular Disease Group, Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/2(2011-02-01), 212-217 0340-5354 258:2<212 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer