caa a22 4500 445810939 CHVBK 20180317145211.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00415-011-6037-6 doi (NATIONALLICENCE)springer-10.1007/s00415-011-6037-6 Short- and long-lasting tinnitus relief induced by transcranial direct current stimulation [Elektronische Daten] [Pierre Garin, Chantal Gilain, Jean-Philippe Van Damme, Katalin de Fays, Jacques Jamart, Michel Ossemann, Yves Vandermeeren] A significant proportion of the population suffers from tinnitus, a bothersome auditory phantom perception that can severely alter the quality of life. Numerous experimental studies suggests that a maladaptive plasticity of the auditory and limbic cortical areas may underlie tinnitus. Accordingly, repetitive transcranial magnetic stimulation (rTMS) has been repeatedly used with success to reduce tinnitus intensity. The potential of transcranial direct current stimulation (tDCS), another promising method of noninvasive brain stimulation, to relieve tinnitus has not been explored systematically. In a double-blind, placebo-controlled and balanced order design, 20patients suffering from chronic untreatable tinnitus were submitted to 20minutes of 1mA anodal, cathodal and sham tDCS targeting the left temporoparietal area. The primary outcome measure was a change in tinnitus intensity or discomfort assessed with a Visual Analogic Scale (VAS) change-scale immediately after tDCS and 1hour later. Compared to sham tDCS, anodal tDCS significantly reduced tinnitus intensity immediately after stimulation; whereas cathodal tDCS failed to do so. The variances of the tinnitus intensity and discomfort VAS change-scales increased dramatically after anodal and cathodal tDCS, whereas they remained virtually unchanged after sham tDCS. Moreover, several patients unexpectedly reported longer-lasting effects (at least several days) such as tinnitus improvement, worsening, or changes in tinnitus features, more frequently after real than sham tDCS. Anodal tDCS is a promising therapeutic tool for modulating tinnitus perception. Moreover, both anodal and cathodal tDCS seem able to alter tinnitus perception and could, thus, be used to trigger plastic changes. The Author(s), 2011 Tinnitus nationallicence Transcranial direct current stimulation nationallicence Repetitive transcranial magnetic stimulation nationallicence Noninvasive brain stimulation nationallicence Brain plasticity nationallicence Garin Pierre Centre Universitaire d'Audiophonologie, Department of Otorhinolaryngology, CHU Mont-Godinne, Université Catholique de Louvain (UCL), Avenue Dr G. Therasse, 5530, Yvoir, Belgium aut Gilain Chantal Centre Universitaire d'Audiophonologie, Department of Otorhinolaryngology, CHU Mont-Godinne, Université Catholique de Louvain (UCL), Avenue Dr G. Therasse, 5530, Yvoir, Belgium aut Van Damme Jean-Philippe Centre Universitaire d'Audiophonologie, Department of Otorhinolaryngology, CHU Mont-Godinne, Université Catholique de Louvain (UCL), Avenue Dr G. Therasse, 5530, Yvoir, Belgium aut de Fays Katalin Department of Neurology, CHU Mont-Godinne, Avenue Dr G. Therasse, 5530, Yvoir, Belgium aut Jamart Jacques Scientific Support Unit, CHU Mont-Godinne, 5530, Yvoir, Belgium aut Ossemann Michel Department of Neurology, CHU Mont-Godinne, Avenue Dr G. Therasse, 5530, Yvoir, Belgium aut Vandermeeren Yves Department of Neurology, CHU Mont-Godinne, Avenue Dr G. Therasse, 5530, Yvoir, Belgium aut Journal of Neurology Springer-Verlag 258/11(2011-11-01), 1940-1948 0340-5354 258:11<1940 2011 258 415 https://doi.org/10.1007/s00415-011-6037-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-6037-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Garin Pierre Centre Universitaire d'Audiophonologie, Department of Otorhinolaryngology, CHU Mont-Godinne, Université Catholique de Louvain (UCL), Avenue Dr G. Therasse, 5530, Yvoir, Belgium aut NATIONALLICENCE 700 1- Gilain Chantal Centre Universitaire d'Audiophonologie, Department of Otorhinolaryngology, CHU Mont-Godinne, Université Catholique de Louvain (UCL), Avenue Dr G. Therasse, 5530, Yvoir, Belgium aut NATIONALLICENCE 700 1- Van Damme Jean-Philippe Centre Universitaire d'Audiophonologie, Department of Otorhinolaryngology, CHU Mont-Godinne, Université Catholique de Louvain (UCL), Avenue Dr G. Therasse, 5530, Yvoir, Belgium aut NATIONALLICENCE 700 1- de Fays Katalin Department of Neurology, CHU Mont-Godinne, Avenue Dr G. Therasse, 5530, Yvoir, Belgium aut NATIONALLICENCE 700 1- Jamart Jacques Scientific Support Unit, CHU Mont-Godinne, 5530, Yvoir, Belgium aut NATIONALLICENCE 700 1- Ossemann Michel Department of Neurology, CHU Mont-Godinne, Avenue Dr G. Therasse, 5530, Yvoir, Belgium aut NATIONALLICENCE 700 1- Vandermeeren Yves Department of Neurology, CHU Mont-Godinne, Avenue Dr G. Therasse, 5530, Yvoir, Belgium aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/11(2011-11-01), 1940-1948 0340-5354 258:11<1940 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer