caa a22 4500 445810947 CHVBK 20180317145211.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00415-011-6074-1 doi (NATIONALLICENCE)springer-10.1007/s00415-011-6074-1 Chorea and related movement disorders of paraneoplastic origin: the PNS EuroNetwork experience [Elektronische Daten] [Maria Vigliani, Jerome Honnorat, Jean-Christophe Antoine, Roberta Vitaliani, Bruno Giometto, Dimitri Psimaras, Federica Franchino, Carlotta Rossi, Francesc Graus] Chorea and other movement disorders are rarely described as paraneoplastic. The aim of this study was to describe 13 patients with paraneoplastic chorea and dystonia collected by the members of the paraneoplastic neurological syndrome (PNS) EuroNetwork and to review 29 cases from the literature. We analyzed neurological symptoms, severity of the neurological syndrome, delay in neurological diagnosis, associated cancer, oncological and neurological treatments received, and outcome. Eleven (1.2%) out of 913 patients with PNS were identified in the EuroNetwork register. Two more patients not included in the register were added. The overall population consisted of 13 patients with a median age of 75years (range 49-82years). In most patients, the movement disorder was classical choreoathetosis with symmetric involvement of the trunk, neck, and limbs. A minority of patients presented unilateral chorea, dystonia, and orobuccal dyskinesia. Associated symptoms, as polyneuropathy, encephalitis, psychiatric disturbances, or visual defects, were often present. The movement disorder usually had a subacute course. The most frequently associated cancer was small cell lung cancer (SCLC). Lymphoma, bowel, or kidney cancers were also reported. CV2/CRMP5 was the most frequently associated antibody, followed by Hu. Hyperintense lesions of the basal ganglia on T2-weighted images were seldom observed. Response to cancer therapy was observed in a minority of patients, but survival was short (17months). As in other neurological diseases, movement disorders should also be suspected as paraneoplastic when they develop subacutely in older patients (usually over 50) and often in the presence of other ancillary neurological symptoms. Springer-Verlag, 2011 Paraneoplastic nationallicence Chorea nationallicence Dystonia nationallicence Movement disorder nationallicence Cancer nationallicence PNS : Paraneoplastic neurological syndrome nationallicence MRS : Modified Rankin scale nationallicence OCD : Obsessive compulsive disorder nationallicence SCLC : Small cell lung cancer nationallicence Non SCLC : Non small cell lung cancer nationallicence HL : Hodgkin's lymphoma nationallicence Non-HL : Non-Hodgkin's lymphoma nationallicence SLE : Systemic lupus erythematosus nationallicence CNS : Central nervous system nationallicence CSF : Cerebrospinal fluid nationallicence MRI : Magnetic resonance imaging nationallicence Vigliani Maria Dipartimento di Neuroscienze, Ospedale San Giovanni Battista, Via Cherasco 15, 10126, Torino, Italy aut Honnorat Jerome Hospices Civils de Lyon, Hôpital Neurologique, Centre de Référence Maladie Rare "Syndromes Neurologiques Paranéoplasiques”, Lyon, France aut Antoine Jean-Christophe Hospices Civils de Lyon, Hôpital Neurologique, Centre de Référence Maladie Rare "Syndromes Neurologiques Paranéoplasiques”, Lyon, France aut Vitaliani Roberta Dipartimento di Neurologia, Ospedale Ca' Foncello, Treviso, Italy aut Giometto Bruno Dipartimento di Neurologia, Ospedale Ca' Foncello, Treviso, Italy aut Psimaras Dimitri Division Mazarin, Hôpital de la Salpetrière, Paris, France aut Franchino Federica Dipartimento di Neuroscienze, Ospedale San Giovanni Battista, Via Cherasco 15, 10126, Torino, Italy aut Rossi Carlotta Istituto Mario Negri, Bergamo, Italy aut Graus Francesc Department of Neurology, Hospital Clinic, Universitat de Barcelona and Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Barcelona, Spain aut Journal of Neurology Springer-Verlag 258/11(2011-11-01), 2058-2068 0340-5354 258:11<2058 2011 258 415 https://doi.org/10.1007/s00415-011-6074-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-6074-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Vigliani Maria Dipartimento di Neuroscienze, Ospedale San Giovanni Battista, Via Cherasco 15, 10126, Torino, Italy aut NATIONALLICENCE 700 1- Honnorat Jerome Hospices Civils de Lyon, Hôpital Neurologique, Centre de Référence Maladie Rare "Syndromes Neurologiques Paranéoplasiques”, Lyon, France aut NATIONALLICENCE 700 1- Antoine Jean-Christophe Hospices Civils de Lyon, Hôpital Neurologique, Centre de Référence Maladie Rare "Syndromes Neurologiques Paranéoplasiques”, Lyon, France aut NATIONALLICENCE 700 1- Vitaliani Roberta Dipartimento di Neurologia, Ospedale Ca' Foncello, Treviso, Italy aut NATIONALLICENCE 700 1- Giometto Bruno Dipartimento di Neurologia, Ospedale Ca' Foncello, Treviso, Italy aut NATIONALLICENCE 700 1- Psimaras Dimitri Division Mazarin, Hôpital de la Salpetrière, Paris, France aut NATIONALLICENCE 700 1- Franchino Federica Dipartimento di Neuroscienze, Ospedale San Giovanni Battista, Via Cherasco 15, 10126, Torino, Italy aut NATIONALLICENCE 700 1- Rossi Carlotta Istituto Mario Negri, Bergamo, Italy aut NATIONALLICENCE 700 1- Graus Francesc Department of Neurology, Hospital Clinic, Universitat de Barcelona and Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Barcelona, Spain aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/11(2011-11-01), 2058-2068 0340-5354 258:11<2058 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer