caa a22 4500 44581098X CHVBK 20180317145211.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00415-011-6059-0 doi (NATIONALLICENCE)springer-10.1007/s00415-011-6059-0 Sonographic assessment of the optic nerve sheath in idiopathic intracranial hypertension [Elektronische Daten] [Jochen Bäuerle, Max Nedelmann] The aim of this work was to investigate the potential of ultrasound-based optic nerve sheath diameter (ONSD) measurements in detecting raised intracranial pressure in patients with idiopathic intracranial hypertension (IIH) and to describe ONSD response to lumbar puncture. In ten patients with newly diagnosed IIH, transorbital sonography was carried out to assess ONSD, OND (optic nerve diameter), and optic disc elevation before and after lumbar puncture. Twenty-five patients with other neurological disorders served as controls. Subjects with IIH showed a significantly enlarged ONSD on both sides (6.4±0.6mm vs. 5.4±0.5mm in controls; p<0.001). The best cut-off value of ONSD for detecting raised ICP was 5.8mm with a sensitivity of 90% and a specificity of 84%. After lumbar puncture, ONSD decreased bilaterally (right 5.8±0.7mm, p<0.004; left 5.9±0.7mm, p<0.043). No post-puncture changes could be observed with regard to OND and optic disc elevation. Sonographic ONSD evaluation may be useful as an additional tool to identify patients with raised intracranial pressure, as in IIH. Furthermore, our data suggest a potential usefulness of this method for monitoring of treatment effects. The degree of ONSD response to lumbar puncture differs in subjects with IIH, which may possibly be related to findings of a defective CSF circulation in the optic nerve sheath in this disorder, a state that is referred to as optic nerve compartment syndrome. Springer-Verlag, 2011 Optic nerve sheath diameter nationallicence Optic nerve sonography nationallicence Idiopathic intracranial hypertension nationallicence Optic nerve diameter nationallicence Bäuerle Jochen Department of Neurology, Justus-Liebig-University, Klinikstraße 33, 35385, Giessen, Germany aut Nedelmann Max Department of Neurology, Justus-Liebig-University, Klinikstraße 33, 35385, Giessen, Germany aut Journal of Neurology Springer-Verlag 258/11(2011-11-01), 2014-2019 0340-5354 258:11<2014 2011 258 415 https://doi.org/10.1007/s00415-011-6059-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-6059-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bäuerle Jochen Department of Neurology, Justus-Liebig-University, Klinikstraße 33, 35385, Giessen, Germany aut NATIONALLICENCE 700 1- Nedelmann Max Department of Neurology, Justus-Liebig-University, Klinikstraße 33, 35385, Giessen, Germany aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/11(2011-11-01), 2014-2019 0340-5354 258:11<2014 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer