caa a22 4500 445811013 CHVBK 20180317145212.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00415-011-6107-9 doi (NATIONALLICENCE)springer-10.1007/s00415-011-6107-9 Congenital mirror movements: a clue to understanding bimanual motor control [Elektronische Daten] [Cécile Galléa, Traian Popa, Ségolène Billot, Aurélie Méneret, Christel Depienne, Emmanuel Roze] Mirror movements (MM) are involuntary movements of one side of the body that accompany and mirror intentional movements on the opposite side. Physiological MM can occur during normal childhood development, probably owing to corpus callosum immaturity. Pathological congenital MM may be clinically isolated or part of a complex congenital syndrome, including Kallmann syndrome, Klippel-Feil syndrome, and congenital hemiplegia. Congenital isolated MM are usually familial. Recently, heterozygous mutations of the DCC gene, with autosomal dominant inheritance, were shown to cause some cases of MM. The pathogenesis of congenital MM may involve (i) abnormal interhemispheric inhibition between the two motor cortices; (ii) functional alteration of motor planning and motor execution; and/or (iii) abnormal persistence of the ipsilateral corticospinal tract. Fundamental and clinical research is providing novel insights into the complex underlying molecular pathways, and recent experimental work has identified several mechanisms that may mediate the motor network dysfunction. In this review, we analyze clinical, genetic, neurophysiologic, and neuroimaging data on congenital MM, and discuss how this knowledge may improve our understanding of bimanual motor control. Springer-Verlag, 2011 Movement disorder nationallicence Corpus callosum nationallicence Corticospinal tract nationallicence SMA nationallicence M1 nationallicence Pathogenic mutations nationallicence Galléa Cécile CENIR, Institut du Cerveau et de la Moelle Epiniere (ICM), Paris, France aut Popa Traian CENIR, Institut du Cerveau et de la Moelle Epiniere (ICM), Paris, France aut Billot Ségolène Service de Neurologie, AP-HP, Hôpital Avicenne, Bobigny, France aut Méneret Aurélie INSERM, UMRS 975, CNRS 7225-CRICM, Pitié-Salpétriêre Hospital, Paris, France aut Depienne Christel INSERM, UMRS 975, CNRS 7225-CRICM, Pitié-Salpétriêre Hospital, Paris, France aut Roze Emmanuel INSERM, UMRS 975, CNRS 7225-CRICM, Pitié-Salpétriêre Hospital, Paris, France aut Journal of Neurology Springer-Verlag 258/11(2011-11-01), 1911-1919 0340-5354 258:11<1911 2011 258 415 https://doi.org/10.1007/s00415-011-6107-9 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-6107-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Galléa Cécile CENIR, Institut du Cerveau et de la Moelle Epiniere (ICM), Paris, France aut NATIONALLICENCE 700 1- Popa Traian CENIR, Institut du Cerveau et de la Moelle Epiniere (ICM), Paris, France aut NATIONALLICENCE 700 1- Billot Ségolène Service de Neurologie, AP-HP, Hôpital Avicenne, Bobigny, France aut NATIONALLICENCE 700 1- Méneret Aurélie INSERM, UMRS 975, CNRS 7225-CRICM, Pitié-Salpétriêre Hospital, Paris, France aut NATIONALLICENCE 700 1- Depienne Christel INSERM, UMRS 975, CNRS 7225-CRICM, Pitié-Salpétriêre Hospital, Paris, France aut NATIONALLICENCE 700 1- Roze Emmanuel INSERM, UMRS 975, CNRS 7225-CRICM, Pitié-Salpétriêre Hospital, Paris, France aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/11(2011-11-01), 1911-1919 0340-5354 258:11<1911 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer