caa a22 4500 445811056 CHVBK 20180317145212.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00415-011-6051-8 doi (NATIONALLICENCE)springer-10.1007/s00415-011-6051-8 Clinical significance of periodic leg movements during sleep in rapid eye movement sleep behavior disorder [Elektronische Daten] [Taeko Sasai, Yuichi Inoue, Masato Matsuura] The aim of the study was to explore the clinical significance of periodic leg movements during sleep (PLMS) in rapid eye movement sleep behavior disorder (RBD) and the pathological relation between these two disorders. Eighty-one consecutive idiopathic RBD (iRBD) patients, classified into two groups—27 patients with PLMS (iRBD-PLMS) and 54 patients without PLMS (iRBD w/o PLMS), and 31 patients with idiopathic PLMS (iPLMS)—were enrolled in this study. Descriptive variables including Epworth Sleepiness Scale (ESS) scores and polysomnography measures were compared among the three patient groups. Correlation analysis between the ratio of PLMS-related arousal index to PLMS index (PLMAI/PLMI) and sleep stage-related variables or clinically descriptive RBD variables was performed in the iRBD-PLMS group. Associated factors indicating the existence of PLMS during both stages NREM and REM were investigated in this group with clinically descriptive RBD variables. The iRBD-PLMS group showed a significantly lower ESS score and PLMAI/PLMI than the iPLMS group. The PLMAI/PLMI value negatively correlated with RWA/REM. RWA/REM was extracted as a factor that was significantly associated with the existence of PLMS during both stages NREM and REM. The RBD morbidity duration appeared as an associated factor for PLMS only during stage REM among the iRBD patients. In iRBD patients, daytime sleepiness remains modest probably because of suppressed cortical reactivity to PLMS. Increased PLMS activity during both stages NREM and REM is related to the mechanism of REM atonia loss caused by brainstem dysfunction. Especially, PLMS during stage REM might reflect the length of RBD morbidity. Springer-Verlag, 2011 REM sleep behavior disorder nationallicence REM sleep without atonia nationallicence Parasomnia nationallicence Periodic leg movements nationallicence Epworth Sleepiness Scale nationallicence α-Synucleinopathy nationallicence Sasai Taeko Japan Somnology Center, Neuropsychiatric Research Institute, 1-17-7 Yoyogi, Tokyo, Shibuya-ku, Japan aut Inoue Yuichi Japan Somnology Center, Neuropsychiatric Research Institute, 1-17-7 Yoyogi, Tokyo, Shibuya-ku, Japan aut Matsuura Masato Division of Biomedical Laboratory Sciences, Department of Life Sciences and Bio-Informatics, Graduate School of Health Sciences, Tokyo Medical and Dental University, Tokyo, Japan aut Journal of Neurology Springer-Verlag 258/11(2011-11-01), 1971-1978 0340-5354 258:11<1971 2011 258 415 https://doi.org/10.1007/s00415-011-6051-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-6051-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sasai Taeko Japan Somnology Center, Neuropsychiatric Research Institute, 1-17-7 Yoyogi, Tokyo, Shibuya-ku, Japan aut NATIONALLICENCE 700 1- Inoue Yuichi Japan Somnology Center, Neuropsychiatric Research Institute, 1-17-7 Yoyogi, Tokyo, Shibuya-ku, Japan aut NATIONALLICENCE 700 1- Matsuura Masato Division of Biomedical Laboratory Sciences, Department of Life Sciences and Bio-Informatics, Graduate School of Health Sciences, Tokyo Medical and Dental University, Tokyo, Japan aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/11(2011-11-01), 1971-1978 0340-5354 258:11<1971 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer