caa a22 4500 445811072 CHVBK 20180317145212.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00415-011-6065-2 doi (NATIONALLICENCE)springer-10.1007/s00415-011-6065-2 Vascular function and multiple sclerosis [Elektronische Daten] [Anette Fjeldstad, John McDaniel, Melissa Witman, Steve Ives, Jia Zhao, John Rose, James Hannon, D. Wray, Russell Richardson] Multiple sclerosis (MS) is a debilitating disease with an assumed autoimmune etiology which may lead to elevated oxidative stress, vascular dysfunction, and subsequent predisposition to cardiovascular disease. Therefore, the primary aim of this study was to evaluate vascular function and the potential role of oxidative stress in patients diagnosed with MS compared to healthy controls (C). Fourteen patients with relapsing-remitting MS (47±3years) and 13 age- and activity-matched controls (44±5years) underwent brachial artery flow-mediated dilation (FMD) and reactive hyperemia testing using ultrasound Doppler. Venous blood was analyzed for C-reactive protein (CRP), lipid hydroperoxides (LH), the ferric reducing ability of plasma (FRAP), superoxide dismutase (SOD), and catalase activity. CRP [1.8±0.5mg/L (MS), 1.0±0.5mg/L (C)] and LH [1.2±0.2μmol/L (MS), 1.1±0.1μmol/L (C)] were not different between MS patients and controls. FMD [8.0±1.2% (MS) and 9.2±1.6% (C)] and reactive hyperemia [380±61mL (MS) and 402±69mL (C)] were also not different between groups. Vascular function, as assessed by both FMD and reactive hyperemia, was not impaired in patients with MS compared to controls. Further, there was no evidence of elevated systemic inflammation or oxidative stress in these patients, who were currently all in remission. These findings suggest that impaired vascular function, elevated inflammation and oxidative stress are not an obligatory accompaniment to MS. Springer-Verlag, 2011 Inflammation nationallicence Reactive hyperemia nationallicence FMD nationallicence Physical activity nationallicence Fjeldstad Anette Division of Geriatrics, Department of Internal Medicine, George E. Whalen VA Medical Center, University of Utah, 500 Foothill Drive, 84148, Salt Lake City, UT, USA aut McDaniel John Geriatric Research, Education, and Clinical Center, VAMC, Salt Lake City, UT, USA aut Witman Melissa Department of Exercise and Sports Science, University of Utah, Salt Lake City, UT, USA aut Ives Steve Department of Exercise and Sports Science, University of Utah, Salt Lake City, UT, USA aut Zhao Jia Division of Geriatrics, Department of Internal Medicine, George E. Whalen VA Medical Center, University of Utah, 500 Foothill Drive, 84148, Salt Lake City, UT, USA aut Rose John Neurovirology Research Laboratory, VASLCHSC, and Department of Neurology, University of Utah, Salt Lake City, UT, USA aut Hannon James Department of Exercise and Sports Science, University of Utah, Salt Lake City, UT, USA aut Wray D. Division of Geriatrics, Department of Internal Medicine, George E. Whalen VA Medical Center, University of Utah, 500 Foothill Drive, 84148, Salt Lake City, UT, USA aut Richardson Russell Division of Geriatrics, Department of Internal Medicine, George E. Whalen VA Medical Center, University of Utah, 500 Foothill Drive, 84148, Salt Lake City, UT, USA aut Journal of Neurology Springer-Verlag 258/11(2011-11-01), 2036-2042 0340-5354 258:11<2036 2011 258 415 https://doi.org/10.1007/s00415-011-6065-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-6065-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fjeldstad Anette Division of Geriatrics, Department of Internal Medicine, George E. Whalen VA Medical Center, University of Utah, 500 Foothill Drive, 84148, Salt Lake City, UT, USA aut NATIONALLICENCE 700 1- McDaniel John Geriatric Research, Education, and Clinical Center, VAMC, Salt Lake City, UT, USA aut NATIONALLICENCE 700 1- Witman Melissa Department of Exercise and Sports Science, University of Utah, Salt Lake City, UT, USA aut NATIONALLICENCE 700 1- Ives Steve Department of Exercise and Sports Science, University of Utah, Salt Lake City, UT, USA aut NATIONALLICENCE 700 1- Zhao Jia Division of Geriatrics, Department of Internal Medicine, George E. Whalen VA Medical Center, University of Utah, 500 Foothill Drive, 84148, Salt Lake City, UT, USA aut NATIONALLICENCE 700 1- Rose John Neurovirology Research Laboratory, VASLCHSC, and Department of Neurology, University of Utah, Salt Lake City, UT, USA aut NATIONALLICENCE 700 1- Hannon James Department of Exercise and Sports Science, University of Utah, Salt Lake City, UT, USA aut NATIONALLICENCE 700 1- Wray D. Division of Geriatrics, Department of Internal Medicine, George E. Whalen VA Medical Center, University of Utah, 500 Foothill Drive, 84148, Salt Lake City, UT, USA aut NATIONALLICENCE 700 1- Richardson Russell Division of Geriatrics, Department of Internal Medicine, George E. Whalen VA Medical Center, University of Utah, 500 Foothill Drive, 84148, Salt Lake City, UT, USA aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/11(2011-11-01), 2036-2042 0340-5354 258:11<2036 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer