caa a22 4500 445811110 CHVBK 20180317145212.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00415-011-6067-0 doi (NATIONALLICENCE)springer-10.1007/s00415-011-6067-0 Gender effect on time to levodopa-induced dyskinesias [Elektronische Daten] [Sharon Hassin-Baer, Irena Molchadski, Oren Cohen, Zeev Nitzan, Lilach Efrati, Olga Tunkel, Evgenia Kozlova, Amos Korczyn] Levodopa-induced dyskinesias (LID) are commonly observed during long-term treatment of patients with Parkinson's disease (PD). The impact of non-pharmacological factors on the latency to LID appearance is not known. The aim of the paper was to identify factors associated with time to appearance of LID. Consecutive PD patients treated with levodopa (n=155) were included in this historical prospective analysis and LID and non-LID groups were compared. The relationship between possible risk factors and the time of LID onset was explored using the Kaplan-Meier method and the Cox multivariate regression model, controlling for the confounding effects of gender, age of disease onset, time to initiation of levodopa treatment, and history of smoking. Patients with LID (57.4%) were significantly younger at disease onset and had a slightly longer latency from diagnosis to levodopa treatment than those without; disease duration and age had no effect on LID appearance. Female gender was associated with a shorter time to LID and the median time to LID was 6years for males and 4years for females (p=0.004). In the multivariate survival analysis a younger age of onset of PD and a longer time from diagnosis to levodopa treatment initiation were also associated with a shorter time to LID appearance (p=0.030 and 0.036, respectively). Female gender is associated with a significantly shorter latency to LID appearance. Younger age at PD diagnosis and a longer time until starting levodopa are associated with both higher likelihood to develop LID, and a shorter latency until LID were observed. Springer-Verlag, 2011 Parkinson's disease nationallicence Levodopa nationallicence Levodopa-induced dyskinesias nationallicence Gender nationallicence Smoking nationallicence Age of onset nationallicence Risk factors nationallicence Hassin-Baer Sharon Department of Neurology, Parkinson and Movement Disorders Clinic, Sagol Neuroscience Center, Chaim Sheba Medical Center, Tel-Hashomer, 52621, Ramat-Gan, Israel aut Molchadski Irena Department of Neurology, Parkinson and Movement Disorders Clinic, Sagol Neuroscience Center, Chaim Sheba Medical Center, Tel-Hashomer, 52621, Ramat-Gan, Israel aut Cohen Oren Department of Neurology, Parkinson and Movement Disorders Clinic, Sagol Neuroscience Center, Chaim Sheba Medical Center, Tel-Hashomer, 52621, Ramat-Gan, Israel aut Nitzan Zeev Department of Neurology, Parkinson and Movement Disorders Clinic, Sagol Neuroscience Center, Chaim Sheba Medical Center, Tel-Hashomer, 52621, Ramat-Gan, Israel aut Efrati Lilach Department of Neurology, Parkinson and Movement Disorders Clinic, Sagol Neuroscience Center, Chaim Sheba Medical Center, Tel-Hashomer, 52621, Ramat-Gan, Israel aut Tunkel Olga Department of Neurology, Parkinson and Movement Disorders Clinic, Sagol Neuroscience Center, Chaim Sheba Medical Center, Tel-Hashomer, 52621, Ramat-Gan, Israel aut Kozlova Evgenia Department of Neurology, Parkinson and Movement Disorders Clinic, Sagol Neuroscience Center, Chaim Sheba Medical Center, Tel-Hashomer, 52621, Ramat-Gan, Israel aut Korczyn Amos Sieratzki Chair of Neurology, Tel Aviv University, Tel-Aviv, Israel aut Journal of Neurology Springer-Verlag 258/11(2011-11-01), 2048-2053 0340-5354 258:11<2048 2011 258 415 https://doi.org/10.1007/s00415-011-6067-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-6067-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hassin-Baer Sharon Department of Neurology, Parkinson and Movement Disorders Clinic, Sagol Neuroscience Center, Chaim Sheba Medical Center, Tel-Hashomer, 52621, Ramat-Gan, Israel aut NATIONALLICENCE 700 1- Molchadski Irena Department of Neurology, Parkinson and Movement Disorders Clinic, Sagol Neuroscience Center, Chaim Sheba Medical Center, Tel-Hashomer, 52621, Ramat-Gan, Israel aut NATIONALLICENCE 700 1- Cohen Oren Department of Neurology, Parkinson and Movement Disorders Clinic, Sagol Neuroscience Center, Chaim Sheba Medical Center, Tel-Hashomer, 52621, Ramat-Gan, Israel aut NATIONALLICENCE 700 1- Nitzan Zeev Department of Neurology, Parkinson and Movement Disorders Clinic, Sagol Neuroscience Center, Chaim Sheba Medical Center, Tel-Hashomer, 52621, Ramat-Gan, Israel aut NATIONALLICENCE 700 1- Efrati Lilach Department of Neurology, Parkinson and Movement Disorders Clinic, Sagol Neuroscience Center, Chaim Sheba Medical Center, Tel-Hashomer, 52621, Ramat-Gan, Israel aut NATIONALLICENCE 700 1- Tunkel Olga Department of Neurology, Parkinson and Movement Disorders Clinic, Sagol Neuroscience Center, Chaim Sheba Medical Center, Tel-Hashomer, 52621, Ramat-Gan, Israel aut NATIONALLICENCE 700 1- Kozlova Evgenia Department of Neurology, Parkinson and Movement Disorders Clinic, Sagol Neuroscience Center, Chaim Sheba Medical Center, Tel-Hashomer, 52621, Ramat-Gan, Israel aut NATIONALLICENCE 700 1- Korczyn Amos Sieratzki Chair of Neurology, Tel Aviv University, Tel-Aviv, Israel aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/11(2011-11-01), 2048-2053 0340-5354 258:11<2048 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer