caa a22 4500 445811137 CHVBK 20180317145212.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00415-011-6064-3 doi (NATIONALLICENCE)springer-10.1007/s00415-011-6064-3 Evaluation of contributing factors to restless legs syndrome in migraine patients [Elektronische Daten] [Shiho Suzuki, Keisuke Suzuki, Masayuki Miyamoto, Tomoyuki Miyamoto, Yuka Watanabe, Ryotaro Takashima, Koichi Hirata] Recent studies have provided evidence for a positive association between migraine and restless legs syndrome (RLS), although the exact mechanisms and contributing factors remain unclear. A cross-sectional, case-control study was conducted, including patients with migraine (n=262) and headache-free control subjects (n=163). Migraine was diagnosed according to International Classification of Headache Disorders II criteria. RLS diagnosis was made based on four essential criteria as described by the International Restless Legs Syndrome Study Group. All patients completed the Migraine Disability Assessment (MIDAS) questionnaire, Beck Depression Inventory (BDI)-II scores, Pittsburgh Sleep Quality Index (PSQI), and Epworth Sleepiness Scale (ESS). A total of 210 blood samples were collected to correlate various parameters with RLS. RLS frequency was significantly greater in patients with migraine than in controls (13.7 vs. 1.8%). Migraine patients with RLS had high scores for MIDAS, BDI-II, PSQI, and ESS compared with those without RLS. In addition, migraine patients with RLS had a high rate of smoking and RLS family history, as well as increased levels of serum phosphorus and urea nitrogen compared with those without RLS. However, there was no difference in serum iron and ferritin levels between the groups. In migraine patients, logistic regression analysis revealed that positive RLS family history, BDI-II, ESS, and serum phosphorus levels were significant RLS predictors. Our study confirmed a positive association between RLS and migraine. RLS comorbidity in migraine patients was associated with insomnia, daytime sleepiness, depressive symptoms, headache-related disability, and increased serum phosphorus levels. These findings may provide a better understanding of RLS pathogenesis in migraine. Springer-Verlag, 2011 Migraine nationallicence Restless legs syndrome nationallicence Sleep disorders nationallicence Depression nationallicence Phosphorus levels nationallicence Suzuki Shiho Department of Neurology, Dokkyo Medical University, 880 Kitakobayashi, 321-0293, Mibu, Tochigi, Japan aut Suzuki Keisuke Department of Neurology, Dokkyo Medical University, 880 Kitakobayashi, 321-0293, Mibu, Tochigi, Japan aut Miyamoto Masayuki Department of Neurology, Dokkyo Medical University, 880 Kitakobayashi, 321-0293, Mibu, Tochigi, Japan aut Miyamoto Tomoyuki Department of Neurology, Dokkyo Medical University, 880 Kitakobayashi, 321-0293, Mibu, Tochigi, Japan aut Watanabe Yuka Department of Neurology, Dokkyo Medical University, 880 Kitakobayashi, 321-0293, Mibu, Tochigi, Japan aut Takashima Ryotaro Department of Neurology, Dokkyo Medical University, 880 Kitakobayashi, 321-0293, Mibu, Tochigi, Japan aut Hirata Koichi Department of Neurology, Dokkyo Medical University, 880 Kitakobayashi, 321-0293, Mibu, Tochigi, Japan aut Journal of Neurology Springer-Verlag 258/11(2011-11-01), 2026-2035 0340-5354 258:11<2026 2011 258 415 https://doi.org/10.1007/s00415-011-6064-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-6064-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Suzuki Shiho Department of Neurology, Dokkyo Medical University, 880 Kitakobayashi, 321-0293, Mibu, Tochigi, Japan aut NATIONALLICENCE 700 1- Suzuki Keisuke Department of Neurology, Dokkyo Medical University, 880 Kitakobayashi, 321-0293, Mibu, Tochigi, Japan aut NATIONALLICENCE 700 1- Miyamoto Masayuki Department of Neurology, Dokkyo Medical University, 880 Kitakobayashi, 321-0293, Mibu, Tochigi, Japan aut NATIONALLICENCE 700 1- Miyamoto Tomoyuki Department of Neurology, Dokkyo Medical University, 880 Kitakobayashi, 321-0293, Mibu, Tochigi, Japan aut NATIONALLICENCE 700 1- Watanabe Yuka Department of Neurology, Dokkyo Medical University, 880 Kitakobayashi, 321-0293, Mibu, Tochigi, Japan aut NATIONALLICENCE 700 1- Takashima Ryotaro Department of Neurology, Dokkyo Medical University, 880 Kitakobayashi, 321-0293, Mibu, Tochigi, Japan aut NATIONALLICENCE 700 1- Hirata Koichi Department of Neurology, Dokkyo Medical University, 880 Kitakobayashi, 321-0293, Mibu, Tochigi, Japan aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/11(2011-11-01), 2026-2035 0340-5354 258:11<2026 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer