caa a22 4500 445811153 CHVBK 20180317145212.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00415-011-6033-x doi (NATIONALLICENCE)springer-10.1007/s00415-011-6033-x Prognostic value of multimodal evoked potentials in multiple sclerosis: the EP score [Elektronische Daten] [Paolo Invernizzi, Laura Bertolasi, Maria Bianchi, Marco Turatti, Alberto Gajofatto, Maria Benedetti] Evoked potentials (EPs) have long been used as diagnostic tools in multiple sclerosis (MS), although their importance decreased as magnetic resonance imaging (MRI) became available. However, the prognostic value of EPs in MS has not been completely established. The aim of the study was to analyze the prognostic significance of EPs in a cohort of MS cases. From the Verona University Hospital MS Clinic database we retrospectively identified 80 MS patients who underwent a complete neurophysiological evaluation, including visual, brain stem, somatosensory and motor EPs and who were followed for at least 5years after the study. EPs abnormalities were quantified through an index of global EPs alteration (EP score). The relationship between EP score and disability in terms of Expanded Disability Status Scale (EDSS) was analyzed by the Kaplan-Meier survival method and Spearman ρ correlation coefficient. ROC curves were used to determine the best EP score cut off to predict different EDSS endpoints. For each endpoint, sensitivity, specificity, positive and negative predictive value of EP score were calculated. We found a significant correlation (p<0.001) between EP score and EDSS score at the time of neurophysiological study and at 1, 3 and 5years of follow-up, particularly for motor and somatosensory EPs. Kaplan-Meier curves confirmed an increased risk of disability in those patients with EP score higher than the median value. EP score of 8 or 9 showed the highest sensitivity and specificity in predicting EDSS 4.0 and 6.0. EPs are reliable procedures to predict disability in MS patients. The correlation between EPs abnormalities and EDSS is higher than between conventional MRI and EDSS. Springer-Verlag, 2011 Multiple sclerosis nationallicence Evoked potentials nationallicence EP score nationallicence EDSS nationallicence Prognosis nationallicence Invernizzi Paolo U.O. Neurologia, Istituto Ospedaliero Fondazione Poliambulanza, via Bissolati, 57, 25123, Brescia, Italy aut Bertolasi Laura Clinica Neurologica, Policlinico G. Rossi, Azienda Ospedaliera Universitaria Integrata, Verona, Italy aut Bianchi Maria Clinica Neurologica, Policlinico G. Rossi, Azienda Ospedaliera Universitaria Integrata, Verona, Italy aut Turatti Marco Clinica Neurologica, Policlinico G. Rossi, Azienda Ospedaliera Universitaria Integrata, Verona, Italy aut Gajofatto Alberto Clinica Neurologica, Policlinico G. Rossi, Azienda Ospedaliera Universitaria Integrata, Verona, Italy aut Benedetti Maria Clinica Neurologica, Policlinico G. Rossi, Azienda Ospedaliera Universitaria Integrata, Verona, Italy aut Journal of Neurology Springer-Verlag 258/11(2011-11-01), 1933-1939 0340-5354 258:11<1933 2011 258 415 https://doi.org/10.1007/s00415-011-6033-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-6033-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Invernizzi Paolo U.O. Neurologia, Istituto Ospedaliero Fondazione Poliambulanza, via Bissolati, 57, 25123, Brescia, Italy aut NATIONALLICENCE 700 1- Bertolasi Laura Clinica Neurologica, Policlinico G. Rossi, Azienda Ospedaliera Universitaria Integrata, Verona, Italy aut NATIONALLICENCE 700 1- Bianchi Maria Clinica Neurologica, Policlinico G. Rossi, Azienda Ospedaliera Universitaria Integrata, Verona, Italy aut NATIONALLICENCE 700 1- Turatti Marco Clinica Neurologica, Policlinico G. Rossi, Azienda Ospedaliera Universitaria Integrata, Verona, Italy aut NATIONALLICENCE 700 1- Gajofatto Alberto Clinica Neurologica, Policlinico G. Rossi, Azienda Ospedaliera Universitaria Integrata, Verona, Italy aut NATIONALLICENCE 700 1- Benedetti Maria Clinica Neurologica, Policlinico G. Rossi, Azienda Ospedaliera Universitaria Integrata, Verona, Italy aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/11(2011-11-01), 1933-1939 0340-5354 258:11<1933 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer