caa a22 4500 445811188 CHVBK 20180317145212.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00415-011-6116-8 doi (NATIONALLICENCE)springer-10.1007/s00415-011-6116-8 Progressive multifocal leukoencephalopathy and natalizumab [Elektronische Daten] [Kerstin Hellwig, Ralf Gold] Natalizumab (TYSABRI®), a specific α4-integrin antagonist, is approved as a second-line treatment of relapsing-remitting MS (RRMS) patients who fail therapy with interferons or as first-line treatment of patients with highly active relapsing-remitting disease. Since the market introduction of natalizumab as a monotherapy in July of 2006, 111 cases of PML have been reported in natalizumab-treated MS patients as of April 2011. This review focuses on the available data regarding risk stratification for PML under long-term natalizumab therapy, and summarizes the current approach for PML management, as a natalizumab treatment complication is not necessarily associated with a fatal outcome. There is a need for development of surrogate markers that would help to better define the risk of PML in individual patients. Springer-Verlag, 2011 Natalizumab nationallicence IRIS nationallicence Multiple sclerosis nationallicence Plasmapheresis nationallicence Hellwig Kerstin Department of Neurology, St. Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791, Bochum, Germany aut Gold Ralf Department of Neurology, St. Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791, Bochum, Germany aut Journal of Neurology Springer-Verlag 258/11(2011-11-01), 1920-1928 0340-5354 258:11<1920 2011 258 415 https://doi.org/10.1007/s00415-011-6116-8 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-6116-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hellwig Kerstin Department of Neurology, St. Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791, Bochum, Germany aut NATIONALLICENCE 700 1- Gold Ralf Department of Neurology, St. Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791, Bochum, Germany aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/11(2011-11-01), 1920-1928 0340-5354 258:11<1920 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer