caa a22 4500 445811196 CHVBK 20180317145212.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00415-011-6132-8 doi (NATIONALLICENCE)springer-10.1007/s00415-011-6132-8 Lacosamide as add-on in brain tumor-related epilepsy: preliminary report on efficacy and tolerability [Elektronische Daten] [M. Maschio, L. Dinapoli, M. Mingoia, F. Sperati, A. Pace, A. Pompili, C. Carapella, A. Vidiri, P. Muti] Lacosamide (LCM) is an antiepileptic drug (AED) that has demonstrated a good efficacy in controlling seizures as an add-on in adult epilepsy. To date, there have been no studies on LCM in patients with brain tumor-related epilepsy (BTRE). To evaluate efficacy and tolerability of LCM as an add-on in BTRE, we followed 14 patients suffering from BTRE who had already been treated with other AEDs and who had not experienced adequate seizure control. Eleven patients underwent chemotherapy while being treated with LCM. Mean duration of follow up was 5.4months (min<1 max 10months). Mean seizure number in the last month prior to the introduction of LCM had been 15.4. At last follow-up, the mean seizure number was reduced to 1.9/month. Lacosamide mean dosage was of 332.1mg/day (min 100 max 400mg/day). Responder rate was 78.6%. One patient discontinued LCM because of side-effects. There were no other reported side-effects. Preliminary data on the use of LCM in add-on in patients with BTRE indicate that this drug may represent a valid alternative as an add-on in this particular patient population. However, larger samples are necessary in order to draw definitive conclusions. Springer-Verlag, 2011 Antiepileptic drugs nationallicence Brain tumor-related epilepsy nationallicence Lacosamide nationallicence Maschio M. Center for Tumor-related Epilepsy, Neurology Unit, Department of Neuroscience and Cervical-Facial Pathology, National Institute for Cancer "Regina Elena”, Via Elio Chianesi 53, 00144, Rome, Italy aut Dinapoli L. Center for Tumor-related Epilepsy, Neurology Unit, Department of Neuroscience and Cervical-Facial Pathology, National Institute for Cancer "Regina Elena”, Via Elio Chianesi 53, 00144, Rome, Italy aut Mingoia M. Center for Tumor-related Epilepsy, Neurology Unit, Department of Neuroscience and Cervical-Facial Pathology, National Institute for Cancer "Regina Elena”, Via Elio Chianesi 53, 00144, Rome, Italy aut Sperati F. Department of Epidemiology, National Institute for Cancer "Regina Elena”, Via Elio Chianesi 53, 00144, Rome, Italy aut Pace A. Neurology Unit, Department of Neuroscience and Cervical-Facial Pathology, National Institute for Cancer "Regina Elena”, Via Elio Chianesi 53, 00144, Rome, Italy aut Pompili A. Division of Neurosurgery, Department of Neuroscience and Cervical-Facial Pathology, National Institute for Cancer "Regina Elena”, Via Elio Chianesi 53, 00144, Rome, Italy aut Carapella C. Division of Neurosurgery, Department of Neuroscience and Cervical-Facial Pathology, National Institute for Cancer "Regina Elena”, Via Elio Chianesi 53, 00144, Rome, Italy aut Vidiri A. Department of Radiology, National Institute for Cancer "Regina Elena”, Via Elio Chianesi 53, 00144, Rome, Italy aut Muti P. Scientific Direction of National Institute for Cancer "Regina Elena”, Via Elio Chianesi 53, 00144, Rome, Italy aut Journal of Neurology Springer-Verlag 258/11(2011-11-01), 2100-2104 0340-5354 258:11<2100 2011 258 415 https://doi.org/10.1007/s00415-011-6132-8 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-6132-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Maschio M. Center for Tumor-related Epilepsy, Neurology Unit, Department of Neuroscience and Cervical-Facial Pathology, National Institute for Cancer "Regina Elena”, Via Elio Chianesi 53, 00144, Rome, Italy aut NATIONALLICENCE 700 1- Dinapoli L. Center for Tumor-related Epilepsy, Neurology Unit, Department of Neuroscience and Cervical-Facial Pathology, National Institute for Cancer "Regina Elena”, Via Elio Chianesi 53, 00144, Rome, Italy aut NATIONALLICENCE 700 1- Mingoia M. Center for Tumor-related Epilepsy, Neurology Unit, Department of Neuroscience and Cervical-Facial Pathology, National Institute for Cancer "Regina Elena”, Via Elio Chianesi 53, 00144, Rome, Italy aut NATIONALLICENCE 700 1- Sperati F. Department of Epidemiology, National Institute for Cancer "Regina Elena”, Via Elio Chianesi 53, 00144, Rome, Italy aut NATIONALLICENCE 700 1- Pace A. Neurology Unit, Department of Neuroscience and Cervical-Facial Pathology, National Institute for Cancer "Regina Elena”, Via Elio Chianesi 53, 00144, Rome, Italy aut NATIONALLICENCE 700 1- Pompili A. Division of Neurosurgery, Department of Neuroscience and Cervical-Facial Pathology, National Institute for Cancer "Regina Elena”, Via Elio Chianesi 53, 00144, Rome, Italy aut NATIONALLICENCE 700 1- Carapella C. Division of Neurosurgery, Department of Neuroscience and Cervical-Facial Pathology, National Institute for Cancer "Regina Elena”, Via Elio Chianesi 53, 00144, Rome, Italy aut NATIONALLICENCE 700 1- Vidiri A. Department of Radiology, National Institute for Cancer "Regina Elena”, Via Elio Chianesi 53, 00144, Rome, Italy aut NATIONALLICENCE 700 1- Muti P. Scientific Direction of National Institute for Cancer "Regina Elena”, Via Elio Chianesi 53, 00144, Rome, Italy aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/11(2011-11-01), 2100-2104 0340-5354 258:11<2100 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer