caa a22 4500 44581120X CHVBK 20180317145212.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00415-011-6050-9 doi (NATIONALLICENCE)springer-10.1007/s00415-011-6050-9 Progressive ascending myelopathy: atypical forms of multiple sclerosis or what else? [Elektronische Daten] [Viviana Nociti, Anna Batocchi, Marco Luigetti, Amelia Conte, Vita Lorusso, Silvia Roiati, Tommaso Tartaglione, Alessandra Del Grande, Mario Sabatelli] The spinal cord can be affected by multiple heterogeneous disorders often difficult to diagnose. We describe ten patients affected by a progressive ascending myelopathy with a poor prognosis. The patients, during the follow-up period, underwent neurological examinations, cerebrospinal fluid analysis, hematological, microbiological, auto-antibodies screening, brain and spinal cord magnetic resonance imaging (MRI) and electroneurophysiological study. At disease onset spinal cord MRI showed ≥1 myelopathic lesions extended for <2 segments and then evidenced a progressive spinal cord atrophy without any new lesion. All patients showed an increase of the visual evoked potential P100 latency. All of them showed two or more clinical recurrences of myelitis and then, after a period ranging from 3 to 5years from the disease onset, a progressive course. Five patients became unresponsive to intravenous high-dose steroid treatments and/or intravenous immunoglobulins and to any other therapeutic attempts, developed a progressive ascending myelopathy to tetraplegia and died from respiratory failure. The other five patients are in progressive phase of the disease with an initial involvement of the upper limbs and show mild cervical spinal cord atrophy at MRI, configuring the early stage of an ascending progressive myelopathy. In our opinion, the more suitable diagnosis is an atypical form of MS although is not possible to exclude a new nosological entity that could be included in the expanding range of spinal cord diseases. Springer-Verlag, 2011 Multiple sclerosis nationallicence Progressive myelopathy nationallicence Transverse myelitis nationallicence Tetraparesis nationallicence Respiratory failure nationallicence Nociti Viviana Department of Neurosciences, Institute of Neurology, Catholic University, Largo A. Gemelli 8, 00167, Rome, Italy aut Batocchi Anna Department of Neurosciences, Institute of Neurology, Catholic University, Largo A. Gemelli 8, 00167, Rome, Italy aut Luigetti Marco Department of Neurosciences, Institute of Neurology, Catholic University, Largo A. Gemelli 8, 00167, Rome, Italy aut Conte Amelia Department of Neurosciences, Institute of Neurology, Catholic University, Largo A. Gemelli 8, 00167, Rome, Italy aut Lorusso Vita Department of Bioimaging and Radiological Sciences, Institute of Radiology, Catholic University, Rome, Italy aut Roiati Silvia Department of Bioimaging and Radiological Sciences, Institute of Radiology, Catholic University, Rome, Italy aut Tartaglione Tommaso Department of Bioimaging and Radiological Sciences, Institute of Radiology, Catholic University, Rome, Italy aut Del Grande Alessandra Department of Neurosciences, Institute of Neurology, Catholic University, Largo A. Gemelli 8, 00167, Rome, Italy aut Sabatelli Mario Department of Neurosciences, Institute of Neurology, Catholic University, Largo A. Gemelli 8, 00167, Rome, Italy aut Journal of Neurology Springer-Verlag 258/11(2011-11-01), 1965-1970 0340-5354 258:11<1965 2011 258 415 https://doi.org/10.1007/s00415-011-6050-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-6050-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nociti Viviana Department of Neurosciences, Institute of Neurology, Catholic University, Largo A. Gemelli 8, 00167, Rome, Italy aut NATIONALLICENCE 700 1- Batocchi Anna Department of Neurosciences, Institute of Neurology, Catholic University, Largo A. Gemelli 8, 00167, Rome, Italy aut NATIONALLICENCE 700 1- Luigetti Marco Department of Neurosciences, Institute of Neurology, Catholic University, Largo A. Gemelli 8, 00167, Rome, Italy aut NATIONALLICENCE 700 1- Conte Amelia Department of Neurosciences, Institute of Neurology, Catholic University, Largo A. Gemelli 8, 00167, Rome, Italy aut NATIONALLICENCE 700 1- Lorusso Vita Department of Bioimaging and Radiological Sciences, Institute of Radiology, Catholic University, Rome, Italy aut NATIONALLICENCE 700 1- Roiati Silvia Department of Bioimaging and Radiological Sciences, Institute of Radiology, Catholic University, Rome, Italy aut NATIONALLICENCE 700 1- Tartaglione Tommaso Department of Bioimaging and Radiological Sciences, Institute of Radiology, Catholic University, Rome, Italy aut NATIONALLICENCE 700 1- Del Grande Alessandra Department of Neurosciences, Institute of Neurology, Catholic University, Largo A. Gemelli 8, 00167, Rome, Italy aut NATIONALLICENCE 700 1- Sabatelli Mario Department of Neurosciences, Institute of Neurology, Catholic University, Largo A. Gemelli 8, 00167, Rome, Italy aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/11(2011-11-01), 1965-1970 0340-5354 258:11<1965 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer