caa a22 4500 445811226 CHVBK 20180317145212.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00415-011-6042-9 doi (NATIONALLICENCE)springer-10.1007/s00415-011-6042-9 Preceding infections and anti-ganglioside antibody profiles assessed by a dot immunoassay in 306 French Guillain-Barré syndrome patients [Elektronische Daten] [Christiane Caudie, Arnaud Quittard Pinon, Didier Taravel, Valérie Sivadon-Tardy, David Orlikowski, Flore Rozenberg, Tarek Sharshar, Jean Raphaël, Jean Gaillard] We describe by an in-house dot immunoassay, specific anti-ganglioside and sulfatide antibodies, by comparing the results from a large group of 134 infected French GBS patients and those from 172 noninfected French GBS and 142 control groups. A recent infection was identified in 134/306 (43.8%) GBS patients: Campylobacter jejuni (24.6%) was the most common agent, followed by cytomegalovirus (12.4%), Mycoplasma pneumoniae (3.2%) and Epstein-Barr virus (1.3%). Anti-ganglioside antibodies were detected in 97/306 (31.7%) of total GBS patients, 82/134 (61.2%) of GBS patients with a recent identified infection and 15/172 (8.7%) of the patients without identified infection. According to the specificities and antibody classes, four specific IgG antibody profiles were individualised against the two major GM1 and GD1a gangliosides in motor axonal C. jejuni-associated GBS variants, against GQ1b and disialylated gangliosides in Miller Fisher syndrome and its variants. One specific IgM profile against GM2 was found in 16/38 (42%) of severe sensory demyelinating CMV-associated GBS and in 8/17 (47%) of subjects with recent CMV infection with no neurological disease. IgG or IgM antibodies to GM1 were found in 5/10M.pneumoniae-infected patients. IgM antibodies to GM1 were observed in the control groups, 15% of the 74 patients with amyotrophic lateral sclerosis, 19% of the 51 patients with chronic inflammatory demyelinating polyneuropathy, and 9% of the 21 healthy control subjects. The fine specificity of the four IgG antibody profiles and the IgM anti-GM2 profile is closely related to the nature of the preceding infections and the pattern of clinical features. Springer-Verlag, 2011 Guillain-Barré syndrome nationallicence Anti-ganglioside antibodies nationallicence Anti-sulfatide antibodies nationallicence Immunodot assay nationallicence Campylobacter jejuni nationallicence Cytomegalovirus nationallicence Caudie Christiane Service de Neurobiologie, Centre de Biologie et de Pathologie Est, Hôpitaux de Lyon, Groupement Hospitalier Est, Bron, 69677, Lyon, France aut Quittard Pinon Arnaud Laboratoire d'Immunologie Centre de Biologie et de Pathologie Sud, Hospices Civils de Lyon, Groupement Hospitalier Sud, 69495, Pierre Bénite, France aut Taravel Didier Service de Neurobiologie, Centre de Biologie et de Pathologie Est, Hôpitaux de Lyon, Groupement Hospitalier Est, Bron, 69677, Lyon, France aut Sivadon-Tardy Valérie Laboratoire de Microbiologie, Hôpital Raymond-Poincaré, 92380, Garches, France aut Orlikowski David Service de Réanimation Médicale, Hôpital Raymond Poincaré, 92380, Garches, France aut Rozenberg Flore Laboratoire de Virologie, Hôpital Saint-Vincent-de-Paul, 75014, Paris, France aut Sharshar Tarek Service de Réanimation Médicale, Hôpital Raymond Poincaré, 92380, Garches, France aut Raphaël Jean Service de Réanimation Médicale, Hôpital Raymond Poincaré, 92380, Garches, France aut Gaillard Jean Laboratoire de Microbiologie, Hôpital Raymond-Poincaré, 92380, Garches, France aut Journal of Neurology Springer-Verlag 258/11(2011-11-01), 1958-1964 0340-5354 258:11<1958 2011 258 415 https://doi.org/10.1007/s00415-011-6042-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-011-6042-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Caudie Christiane Service de Neurobiologie, Centre de Biologie et de Pathologie Est, Hôpitaux de Lyon, Groupement Hospitalier Est, Bron, 69677, Lyon, France aut NATIONALLICENCE 700 1- Quittard Pinon Arnaud Laboratoire d'Immunologie Centre de Biologie et de Pathologie Sud, Hospices Civils de Lyon, Groupement Hospitalier Sud, 69495, Pierre Bénite, France aut NATIONALLICENCE 700 1- Taravel Didier Service de Neurobiologie, Centre de Biologie et de Pathologie Est, Hôpitaux de Lyon, Groupement Hospitalier Est, Bron, 69677, Lyon, France aut NATIONALLICENCE 700 1- Sivadon-Tardy Valérie Laboratoire de Microbiologie, Hôpital Raymond-Poincaré, 92380, Garches, France aut NATIONALLICENCE 700 1- Orlikowski David Service de Réanimation Médicale, Hôpital Raymond Poincaré, 92380, Garches, France aut NATIONALLICENCE 700 1- Rozenberg Flore Laboratoire de Virologie, Hôpital Saint-Vincent-de-Paul, 75014, Paris, France aut NATIONALLICENCE 700 1- Sharshar Tarek Service de Réanimation Médicale, Hôpital Raymond Poincaré, 92380, Garches, France aut NATIONALLICENCE 700 1- Raphaël Jean Service de Réanimation Médicale, Hôpital Raymond Poincaré, 92380, Garches, France aut NATIONALLICENCE 700 1- Gaillard Jean Laboratoire de Microbiologie, Hôpital Raymond-Poincaré, 92380, Garches, France aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/11(2011-11-01), 1958-1964 0340-5354 258:11<1958 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer