caa a22 4500 445812621 CHVBK 20180317145216.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00411-010-0335-8 doi (NATIONALLICENCE)springer-10.1007/s00411-010-0335-8 Preliminary assessment of the risks associated with solar ultraviolet-A exposure [Elektronische Daten] [Boyan Petkov, Vito Vitale, Claudio Tomasi, Emanuela Gadaleta, Mauro Mazzola, Christian Lanconelli, Angelo Lupi, Maurizio Busetto, Elena Benedetti] An approach is proposed to assess the periods of human skin exposure to solar ultraviolet-A (UV-A, 315-400nm) irradiance in natural conditions that are able to yield doses found to trigger carcinogenesis in laboratory experiments. Weighting functions, adopted to perform such estimate are constructed, allowing for a comparison between environmental and laboratory doses. Furthermore, the impact of stratum corneum (SC) thickness on the studied environmental doses was investigated. Based on laboratory studies, it was found that exposure periods of less than a month, at mid-latitudes, could provide irradiance doses capable of causing tumor formation. The duration of these exposure periods closely depends on the exposure regime, atmospheric conditions and SC thickness. It is believed that the presented evaluations could provide a useful preliminary estimation of the risk associated with environmental UV-A exposure prior to the formulation of the corresponding action spectra and determination of the threshold doses. Springer-Verlag, 2010 Petkov Boyan Institute of Atmospheric Sciences and Climate (ISAC) of the Italian National Research Council (CNR), Via Gobetti 101, 40129, Bologna, Italy aut Vitale Vito Institute of Atmospheric Sciences and Climate (ISAC) of the Italian National Research Council (CNR), Via Gobetti 101, 40129, Bologna, Italy aut Tomasi Claudio Institute of Atmospheric Sciences and Climate (ISAC) of the Italian National Research Council (CNR), Via Gobetti 101, 40129, Bologna, Italy aut Gadaleta Emanuela Centre for Molecular Oncology and Imaging, Institute of Cancer and CR-UK Clinical Centre, Barts and The London School of Medicine (QMUL), London, UK aut Mazzola Mauro Institute of Atmospheric Sciences and Climate (ISAC) of the Italian National Research Council (CNR), Via Gobetti 101, 40129, Bologna, Italy aut Lanconelli Christian Institute of Atmospheric Sciences and Climate (ISAC) of the Italian National Research Council (CNR), Via Gobetti 101, 40129, Bologna, Italy aut Lupi Angelo Institute of Atmospheric Sciences and Climate (ISAC) of the Italian National Research Council (CNR), Via Gobetti 101, 40129, Bologna, Italy aut Busetto Maurizio Institute of Atmospheric Sciences and Climate (ISAC) of the Italian National Research Council (CNR), Via Gobetti 101, 40129, Bologna, Italy aut Benedetti Elena Institute of Acoustics "O.M. Corbino”—ICES Group, Italian National Research Council (CNR), Via Fosso del Cavaliere 100, 00133, Roma Tor Vergata, Italy aut Radiation and Environmental Biophysics Springer-Verlag 50/1(2011-03-01), 219-229 0301-634X 50:1<219 2011 50 411 https://doi.org/10.1007/s00411-010-0335-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00411-010-0335-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Petkov Boyan Institute of Atmospheric Sciences and Climate (ISAC) of the Italian National Research Council (CNR), Via Gobetti 101, 40129, Bologna, Italy aut NATIONALLICENCE 700 1- Vitale Vito Institute of Atmospheric Sciences and Climate (ISAC) of the Italian National Research Council (CNR), Via Gobetti 101, 40129, Bologna, Italy aut NATIONALLICENCE 700 1- Tomasi Claudio Institute of Atmospheric Sciences and Climate (ISAC) of the Italian National Research Council (CNR), Via Gobetti 101, 40129, Bologna, Italy aut NATIONALLICENCE 700 1- Gadaleta Emanuela Centre for Molecular Oncology and Imaging, Institute of Cancer and CR-UK Clinical Centre, Barts and The London School of Medicine (QMUL), London, UK aut NATIONALLICENCE 700 1- Mazzola Mauro Institute of Atmospheric Sciences and Climate (ISAC) of the Italian National Research Council (CNR), Via Gobetti 101, 40129, Bologna, Italy aut NATIONALLICENCE 700 1- Lanconelli Christian Institute of Atmospheric Sciences and Climate (ISAC) of the Italian National Research Council (CNR), Via Gobetti 101, 40129, Bologna, Italy aut NATIONALLICENCE 700 1- Lupi Angelo Institute of Atmospheric Sciences and Climate (ISAC) of the Italian National Research Council (CNR), Via Gobetti 101, 40129, Bologna, Italy aut NATIONALLICENCE 700 1- Busetto Maurizio Institute of Atmospheric Sciences and Climate (ISAC) of the Italian National Research Council (CNR), Via Gobetti 101, 40129, Bologna, Italy aut NATIONALLICENCE 700 1- Benedetti Elena Institute of Acoustics "O.M. Corbino”—ICES Group, Italian National Research Council (CNR), Via Fosso del Cavaliere 100, 00133, Roma Tor Vergata, Italy aut NATIONALLICENCE 773 0- Radiation and Environmental Biophysics Springer-Verlag 50/1(2011-03-01), 219-229 0301-634X 50:1<219 2011 50 411 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer