caa a22 4500 445812656 CHVBK 20180317145216.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00411-010-0328-7 doi (NATIONALLICENCE)springer-10.1007/s00411-010-0328-7 A two-mutation model of radiation-induced acute myeloid leukemia using historical mouse data [Elektronische Daten] [Fieke Dekkers, Harmen Bijwaard, Simon Bouffler, Michele Ellender, René Huiskamp, Christine Kowalczuk, Emmy Meijne, Marjolein Sutmuller] From studies of the atomic bomb survivors, it is well known that ionizing radiation causes several forms of leukemia. However, since the specific mechanism behind this process remains largely unknown, it is difficult to extrapolate carcinogenic effects at acute high-dose exposures to risk estimates for the chronic low-dose exposures that are important for radiation protection purposes. Recently, it has become clear that the induction of acute myeloid leukemia (AML) in CBA/H mice takes place through two key steps, both involving the Sfpi1 gene. A similar mechanism may play a role in human radiation-induced AML. In the present paper, a two-mutation carcinogenesis model is applied to model AML in several data sets of X-ray- and neutron-exposed CBA/H mice. The models obtained provide good fits to the data. A comparison between the predictions for neutron-induced and X-ray-induced AML yields an RBE for neutrons of approximately 3. The model used is considered to be a first step toward a model for human radiation-induced AML, which could be used to estimate risks of exposure to low doses. Springer-Verlag, 2010 Dekkers Fieke Laboratory of Radiation Research, Bilthoven, The Netherlands aut Bijwaard Harmen Laboratory of Radiation Research, Bilthoven, The Netherlands aut Bouffler Simon Health Protection Agency (HPA), Radiation Protection Division, Chilton, United Kingdom aut Ellender Michele Health Protection Agency (HPA), Radiation Protection Division, Chilton, United Kingdom aut Huiskamp René Nuclear Research and Consultancy Group (NRG), Radiation & Environment, Petten, The Netherlands aut Kowalczuk Christine Health Protection Agency (HPA), Radiation Protection Division, Chilton, United Kingdom aut Meijne Emmy Nuclear Research and Consultancy Group (NRG), Radiation & Environment, Petten, The Netherlands aut Sutmuller Marjolein Nuclear Research and Consultancy Group (NRG), Radiation & Environment, Petten, The Netherlands aut Radiation and Environmental Biophysics Springer-Verlag 50/1(2011-03-01), 37-45 0301-634X 50:1<37 2011 50 411 https://doi.org/10.1007/s00411-010-0328-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00411-010-0328-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dekkers Fieke Laboratory of Radiation Research, Bilthoven, The Netherlands aut NATIONALLICENCE 700 1- Bijwaard Harmen Laboratory of Radiation Research, Bilthoven, The Netherlands aut NATIONALLICENCE 700 1- Bouffler Simon Health Protection Agency (HPA), Radiation Protection Division, Chilton, United Kingdom aut NATIONALLICENCE 700 1- Ellender Michele Health Protection Agency (HPA), Radiation Protection Division, Chilton, United Kingdom aut NATIONALLICENCE 700 1- Huiskamp René Nuclear Research and Consultancy Group (NRG), Radiation & Environment, Petten, The Netherlands aut NATIONALLICENCE 700 1- Kowalczuk Christine Health Protection Agency (HPA), Radiation Protection Division, Chilton, United Kingdom aut NATIONALLICENCE 700 1- Meijne Emmy Nuclear Research and Consultancy Group (NRG), Radiation & Environment, Petten, The Netherlands aut NATIONALLICENCE 700 1- Sutmuller Marjolein Nuclear Research and Consultancy Group (NRG), Radiation & Environment, Petten, The Netherlands aut NATIONALLICENCE 773 0- Radiation and Environmental Biophysics Springer-Verlag 50/1(2011-03-01), 37-45 0301-634X 50:1<37 2011 50 411 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer