caa a22 4500 445812699 CHVBK 20180317145216.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00411-010-0340-y doi (NATIONALLICENCE)springer-10.1007/s00411-010-0340-y Thyroid cancer incidence in Ukraine: trends with reference to the Chernobyl accident [Elektronische Daten] [M. Fuzik, A. Prysyazhnyuk, Y. Shibata, A. Romanenko, Z. Fedorenko, L. Gulak, Y. Goroh, N. Gudzenko, N. Trotsyuk, O. Khukhrianska, V. Saenko, S. Yamashita] For the first time, a comparative analysis of thyroid cancer incidence in Ukraine after the Chernobyl accident was done in a cohort that is almost as large as the general population. On the basis of thyroid doses from radioactive iodine in individuals aged 1-18years at the time of accident, geographic regions of Ukraine with low and high average accumulated thyroid doses were established and designated "low-exposure” and "high-exposure” territories, respectively. A significant difference of thyroid cancer incidence rates as a function of time between the two territories was found. That is, the increase in the incidence was higher in high-exposure regions than in low-exposure regions. The incidence rates varied substantially among the different attained age-groups, especially in the youngest one (up to 19years old). The analysis that was adjusted for screening and technological effects also indicated that in the high-exposure regions, thyroid cancer incidence rates at the age of diagnosis of 5-9, 10-14 and 15-19years were significantly higher in those born in 1982-1986 compared to those born in 1987-1991, while in the low-exposure regions, no significant difference was observed. The observed probable excess of radiation-induced thyroid cancer cases in adults exposed to radioactive iodine from the Chernobyl accident, especially in females, may be due to the high power of the present study. However, it should be noted that our investigation was not essentially free from ecological biases. Springer-Verlag, 2010 Fuzik M. Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, 852-8523, Nagasaki, Japan aut Prysyazhnyuk A. Research Centre for Radiation Medicine, National Academy of Medical Sciences of Ukraine, 53 Melnikov Str., 04050, Kyiv, Ukraine aut Shibata Y. Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, 852-8523, Nagasaki, Japan aut Romanenko A. Research Centre for Radiation Medicine, National Academy of Medical Sciences of Ukraine, 53 Melnikov Str., 04050, Kyiv, Ukraine aut Fedorenko Z. National Cancer Institute, Ministry of Health of Ukraine, 33/43 Lomonosov Str., 03022, Kiev, Ukraine aut Gulak L. National Cancer Institute, Ministry of Health of Ukraine, 33/43 Lomonosov Str., 03022, Kiev, Ukraine aut Goroh Y. National Cancer Institute, Ministry of Health of Ukraine, 33/43 Lomonosov Str., 03022, Kiev, Ukraine aut Gudzenko N. Research Centre for Radiation Medicine, National Academy of Medical Sciences of Ukraine, 53 Melnikov Str., 04050, Kyiv, Ukraine aut Trotsyuk N. Research Centre for Radiation Medicine, National Academy of Medical Sciences of Ukraine, 53 Melnikov Str., 04050, Kyiv, Ukraine aut Khukhrianska O. Research Centre for Radiation Medicine, National Academy of Medical Sciences of Ukraine, 53 Melnikov Str., 04050, Kyiv, Ukraine aut Saenko V. Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, 852-8523, Nagasaki, Japan aut Yamashita S. Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, 852-8523, Nagasaki, Japan aut Radiation and Environmental Biophysics Springer-Verlag 50/1(2011-03-01), 47-55 0301-634X 50:1<47 2011 50 411 https://doi.org/10.1007/s00411-010-0340-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00411-010-0340-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fuzik M. Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, 852-8523, Nagasaki, Japan aut NATIONALLICENCE 700 1- Prysyazhnyuk A. Research Centre for Radiation Medicine, National Academy of Medical Sciences of Ukraine, 53 Melnikov Str., 04050, Kyiv, Ukraine aut NATIONALLICENCE 700 1- Shibata Y. Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, 852-8523, Nagasaki, Japan aut NATIONALLICENCE 700 1- Romanenko A. Research Centre for Radiation Medicine, National Academy of Medical Sciences of Ukraine, 53 Melnikov Str., 04050, Kyiv, Ukraine aut NATIONALLICENCE 700 1- Fedorenko Z. National Cancer Institute, Ministry of Health of Ukraine, 33/43 Lomonosov Str., 03022, Kiev, Ukraine aut NATIONALLICENCE 700 1- Gulak L. National Cancer Institute, Ministry of Health of Ukraine, 33/43 Lomonosov Str., 03022, Kiev, Ukraine aut NATIONALLICENCE 700 1- Goroh Y. National Cancer Institute, Ministry of Health of Ukraine, 33/43 Lomonosov Str., 03022, Kiev, Ukraine aut NATIONALLICENCE 700 1- Gudzenko N. Research Centre for Radiation Medicine, National Academy of Medical Sciences of Ukraine, 53 Melnikov Str., 04050, Kyiv, Ukraine aut NATIONALLICENCE 700 1- Trotsyuk N. Research Centre for Radiation Medicine, National Academy of Medical Sciences of Ukraine, 53 Melnikov Str., 04050, Kyiv, Ukraine aut NATIONALLICENCE 700 1- Khukhrianska O. Research Centre for Radiation Medicine, National Academy of Medical Sciences of Ukraine, 53 Melnikov Str., 04050, Kyiv, Ukraine aut NATIONALLICENCE 700 1- Saenko V. Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, 852-8523, Nagasaki, Japan aut NATIONALLICENCE 700 1- Yamashita S. Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, 852-8523, Nagasaki, Japan aut NATIONALLICENCE 773 0- Radiation and Environmental Biophysics Springer-Verlag 50/1(2011-03-01), 47-55 0301-634X 50:1<47 2011 50 411 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer