caa a22 4500 445812737 CHVBK 20180317145217.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00411-010-0345-6 doi (NATIONALLICENCE)springer-10.1007/s00411-010-0345-6 Boron neutron capture therapy (BNCT) for the treatment of liver metastases: biodistribution studies of boron compounds in an experimental model [Elektronische Daten] [Marcela Garabalino, Andrea Monti Hughes, Ana Molinari, Elisa Heber, Emiliano Pozzi, Jorge Cardoso, Lucas Colombo, Susana Nievas, David Nigg, Romina Aromando, Maria Itoiz, Verónica Trivillin, Amanda Schwint] We previously demonstrated the therapeutic efficacy of different boron neutron capture therapy (BNCT) protocols in an experimental model of oral cancer. BNCT is based on the selective accumulation of 10B carriers in a tumor followed by neutron irradiation. Within the context of exploring the potential therapeutic efficacy of BNCT for the treatment of liver metastases, the aim of the present study was to perform boron biodistribution studies in an experimental model of liver metastases in rats. Different boron compounds and administration conditions were assayed to determine which administration protocols would potentially be therapeutically useful in in vivo BNCT studies at the RA-3 nuclear reactor. A total of 70 BDIX rats were inoculated in the liver with syngeneic colon cancer cells DHD/K12/TRb to induce the development of subcapsular tumor nodules. Fourteen days post-inoculation, the animals were used for biodistribution studies. We evaluated a total of 11 administration protocols for the boron compounds boronophenylalanine (BPA) and GB-10 (Na210B10H10), alone or combined at different dose levels and employing different administration routes. Tumor, normal tissue, and blood samples were processed for boron measurement by atomic emission spectroscopy. Six protocols proved potentially useful for BNCT studies in terms of absolute boron concentration in tumor and preferential uptake of boron by tumor tissue. Boron concentration values in tumor and normal tissues in the liver metastases model show it would be feasible to reach therapeutic BNCT doses in tumor without exceeding radiotolerance in normal tissue at the thermal neutron facility at RA-3. Springer-Verlag, 2010 Garabalino Marcela Department of Radiobiology, National Atomic Energy Commission, Avenida General Paz 1499, B1650KNA, San Martin, Province Buenos Aires, Argentina aut Monti Hughes Andrea Department of Radiobiology, National Atomic Energy Commission, Avenida General Paz 1499, B1650KNA, San Martin, Province Buenos Aires, Argentina aut Molinari Ana Department of Radiobiology, National Atomic Energy Commission, Avenida General Paz 1499, B1650KNA, San Martin, Province Buenos Aires, Argentina aut Heber Elisa Department of Radiobiology, National Atomic Energy Commission, Avenida General Paz 1499, B1650KNA, San Martin, Province Buenos Aires, Argentina aut Pozzi Emiliano Department of Radiobiology, National Atomic Energy Commission, Avenida General Paz 1499, B1650KNA, San Martin, Province Buenos Aires, Argentina aut Cardoso Jorge Oncology Institute Angel H. Roffo, Avenida San Martin 5481, Ciudad Autónoma de Buenos Aires, Argentina aut Colombo Lucas Oncology Institute Angel H. Roffo, Avenida San Martin 5481, Ciudad Autónoma de Buenos Aires, Argentina aut Nievas Susana Department of Chemistry, National Atomic Energy Commission, Avenida General Paz 1499, B1650KNA, San Martin, Province Buenos Aires, Argentina aut Nigg David Idaho National Laboratory, 2525 North Fremont Street, P.O. Box 1625, 83415, Idaho Falls, ID, USA aut Aromando Romina Department of Oral Pathology, Faculty of Dentistry, University of Buenos Aires, Marcelo T. de Alvear 2142, 1122, Ciudad Autónoma de Buenos Aires, Argentina aut Itoiz Maria Department of Radiobiology, National Atomic Energy Commission, Avenida General Paz 1499, B1650KNA, San Martin, Province Buenos Aires, Argentina aut Trivillin Verónica Department of Radiobiology, National Atomic Energy Commission, Avenida General Paz 1499, B1650KNA, San Martin, Province Buenos Aires, Argentina aut Schwint Amanda Department of Radiobiology, National Atomic Energy Commission, Avenida General Paz 1499, B1650KNA, San Martin, Province Buenos Aires, Argentina aut Radiation and Environmental Biophysics Springer-Verlag 50/1(2011-03-01), 199-207 0301-634X 50:1<199 2011 50 411 https://doi.org/10.1007/s00411-010-0345-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00411-010-0345-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Garabalino Marcela Department of Radiobiology, National Atomic Energy Commission, Avenida General Paz 1499, B1650KNA, San Martin, Province Buenos Aires, Argentina aut NATIONALLICENCE 700 1- Monti Hughes Andrea Department of Radiobiology, National Atomic Energy Commission, Avenida General Paz 1499, B1650KNA, San Martin, Province Buenos Aires, Argentina aut NATIONALLICENCE 700 1- Molinari Ana Department of Radiobiology, National Atomic Energy Commission, Avenida General Paz 1499, B1650KNA, San Martin, Province Buenos Aires, Argentina aut NATIONALLICENCE 700 1- Heber Elisa Department of Radiobiology, National Atomic Energy Commission, Avenida General Paz 1499, B1650KNA, San Martin, Province Buenos Aires, Argentina aut NATIONALLICENCE 700 1- Pozzi Emiliano Department of Radiobiology, National Atomic Energy Commission, Avenida General Paz 1499, B1650KNA, San Martin, Province Buenos Aires, Argentina aut NATIONALLICENCE 700 1- Cardoso Jorge Oncology Institute Angel H. Roffo, Avenida San Martin 5481, Ciudad Autónoma de Buenos Aires, Argentina aut NATIONALLICENCE 700 1- Colombo Lucas Oncology Institute Angel H. Roffo, Avenida San Martin 5481, Ciudad Autónoma de Buenos Aires, Argentina aut NATIONALLICENCE 700 1- Nievas Susana Department of Chemistry, National Atomic Energy Commission, Avenida General Paz 1499, B1650KNA, San Martin, Province Buenos Aires, Argentina aut NATIONALLICENCE 700 1- Nigg David Idaho National Laboratory, 2525 North Fremont Street, P.O. Box 1625, 83415, Idaho Falls, ID, USA aut NATIONALLICENCE 700 1- Aromando Romina Department of Oral Pathology, Faculty of Dentistry, University of Buenos Aires, Marcelo T. de Alvear 2142, 1122, Ciudad Autónoma de Buenos Aires, Argentina aut NATIONALLICENCE 700 1- Itoiz Maria Department of Radiobiology, National Atomic Energy Commission, Avenida General Paz 1499, B1650KNA, San Martin, Province Buenos Aires, Argentina aut NATIONALLICENCE 700 1- Trivillin Verónica Department of Radiobiology, National Atomic Energy Commission, Avenida General Paz 1499, B1650KNA, San Martin, Province Buenos Aires, Argentina aut NATIONALLICENCE 700 1- Schwint Amanda Department of Radiobiology, National Atomic Energy Commission, Avenida General Paz 1499, B1650KNA, San Martin, Province Buenos Aires, Argentina aut NATIONALLICENCE 773 0- Radiation and Environmental Biophysics Springer-Verlag 50/1(2011-03-01), 199-207 0301-634X 50:1<199 2011 50 411 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer