caa a22 4500 445812753 CHVBK 20180317145217.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00411-010-0333-x doi (NATIONALLICENCE)springer-10.1007/s00411-010-0333-x Effects of acute low doses of Gamma-radiation on erythrocytes membrane [Elektronische Daten] [Sherif Mahmoud, Eman El-Sakhawy, Eman Abdel-Fatah, Adel Kelany, Rizk Rizk] It is believed that any dose of ionizing radiation may damage cells and that the mutated cells could develop into cancer cells. Additionally, results of research performed over the past century on the effects of low doses of ionizing radiation on biological organisms show beneficial health effects, called hormesis. Much less is known about the cellular response to low doses of ionizing radiation, such as those typical for medical diagnostic procedures, normal occupational exposures or cosmic-ray exposures at flight altitudes. Extrapolating from the effects observed at higher doses to predict changes in cells after low-dose exposure is problematic. We examined the biological effects of low doses (0.01-0.3Gy) of γ-radiation on the membrane characteristics of erythrocytes of albino rats and carried out osmotic fragility tests and Fourier transform infrared spectroscopy (FTIR). Our results indicate that the lowest three doses in the investigated radiation range, i.e., 0.01, 0.025 and 0.05Gy, resulted in positive effects on the erythrocyte membranes, while a dose of 0.1Gy appeared to represent the limiting threshold dose of those positive effects. Doses higher than 0.1Gy were associated with the denaturation of erythrocyte proteins. Springer-Verlag, 2010 Mahmoud Sherif Biophysics and Laser Science Unit, Research Institute of Ophthalmology, P.O. Box: 90, Giza, Egypt aut El-Sakhawy Eman Physics Department, Helwan University, Helwan, Egypt aut Abdel-Fatah Eman Radiation Dosimetry Department, National Institute of Standards, Giza, Egypt aut Kelany Adel Physics Department, Helwan University, Helwan, Egypt aut Rizk Rizk Physics Department, Helwan University, Helwan, Egypt aut Radiation and Environmental Biophysics Springer-Verlag 50/1(2011-03-01), 189-198 0301-634X 50:1<189 2011 50 411 https://doi.org/10.1007/s00411-010-0333-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00411-010-0333-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mahmoud Sherif Biophysics and Laser Science Unit, Research Institute of Ophthalmology, P.O. Box: 90, Giza, Egypt aut NATIONALLICENCE 700 1- El-Sakhawy Eman Physics Department, Helwan University, Helwan, Egypt aut NATIONALLICENCE 700 1- Abdel-Fatah Eman Radiation Dosimetry Department, National Institute of Standards, Giza, Egypt aut NATIONALLICENCE 700 1- Kelany Adel Physics Department, Helwan University, Helwan, Egypt aut NATIONALLICENCE 700 1- Rizk Rizk Physics Department, Helwan University, Helwan, Egypt aut NATIONALLICENCE 773 0- Radiation and Environmental Biophysics Springer-Verlag 50/1(2011-03-01), 189-198 0301-634X 50:1<189 2011 50 411 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer