caa a22 4500 445812842 CHVBK 20180317145217.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00411-011-0372-y doi (NATIONALLICENCE)springer-10.1007/s00411-011-0372-y Cytogenetic effects induced by accelerated carbon ions with shielding [Elektronische Daten] [Z. Wang, W. Li, B. Wang, B. Zhang, J. Xing, X. Jing, B. Dang, W. Wei, W. Zhao] Our work aims to understand the effects of shielding on the induction of biological damage by heavy charged particles and to compare the shielding effects of different materials at the same LET from two aspects: the biological effectiveness including or not including secondary particles emitted at large angles and the biological effectiveness at different angles with respect to the beam direction. We designed and conducted biological experiments to determine the biological effectiveness of 200MeV/u carbon ions after traversing different shielding materials (Lucite and aluminium). Whole blood samples, which were either attached to the shielding material (48mm Lucite or 29mm aluminium)or positioned at 300cm away from it at different angles with respect to the beam axis, were exposed to carbon ion beams. For comparison, whole blood samples were exposed directly to 200MeV/u carbon ions. Chromosomal aberrations in lymphocytes were scored. The results indicated that the biological effectiveness per unit dose was not significantly changed by 48mm Lucite or 29mm aluminium, and no significant differences were observed in lymphocytes attached to the target and in lymphocytes positioned at a distance of 300cm away from the target, at 0º angle of the beam axis. However, when plotted as a function of the number of ions hitting the shielding target, the curves are separated and the shield increases the effectiveness per unit ion. The frequency of chromosomal aberrations at tilted angles behind 29mm Al and 48mm Lucite was almost the same. These lesions were considered to be caused by secondary particles due to the passage of particles through the shielding materials. Springer-Verlag, 2011 Wang Z. Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China aut Li W. Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China aut Wang B. Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China aut Zhang B. Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China aut Xing J. Xiangning People's Hospital of Shanxi Province, Xiangning, China aut Jing X. Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China aut Dang B. Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China aut Wei W. Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China aut Zhao W. Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China aut Radiation and Environmental Biophysics Springer-Verlag 50/3(2011-08-01), 383-387 0301-634X 50:3<383 2011 50 411 https://doi.org/10.1007/s00411-011-0372-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00411-011-0372-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang Z. Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China aut NATIONALLICENCE 700 1- Li W. Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China aut NATIONALLICENCE 700 1- Wang B. Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China aut NATIONALLICENCE 700 1- Zhang B. Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China aut NATIONALLICENCE 700 1- Xing J. Xiangning People's Hospital of Shanxi Province, Xiangning, China aut NATIONALLICENCE 700 1- Jing X. Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China aut NATIONALLICENCE 700 1- Dang B. Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China aut NATIONALLICENCE 700 1- Wei W. Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China aut NATIONALLICENCE 700 1- Zhao W. Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China aut NATIONALLICENCE 773 0- Radiation and Environmental Biophysics Springer-Verlag 50/3(2011-08-01), 383-387 0301-634X 50:3<383 2011 50 411 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer