caa a22 4500 445812885 CHVBK 20180317145217.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00411-011-0371-z doi (NATIONALLICENCE)springer-10.1007/s00411-011-0371-z Confocal microscopy for modeling electron microbeam irradiation of skin [Elektronische Daten] [John Miller, William Chrisler, Xihai Wang, Marianne Sowa] For radiation exposures employing targeted sources such as particle microbeams, the deposition of energy and dose will depend on the spatial heterogeneity of the sample. Although cell structural variations are relatively minor for two-dimensional cell cultures, they can vary significantly for fully differentiated tissues. Employing high-resolution confocal microscopy, we have determined the spatial distribution, size, and shape of epidermal keratinocyte nuclei for the full-thickness EpiDerm™ skin model (MatTek, Ashland, VA). Application of these data to calculate the microdosimetry and microdistribution of energy deposition by an electron microbeam is discussed. Springer-Verlag, 2011 Miller John School of Electrical Engineering and Computer Science, Washington State University Tri-Cities, 2710 University Drive, 99354, Richland, WA, USA aut Chrisler William Cell Biology and Biochemistry, Pacific Northwest National Laboratory, 99354, Richland, WA, USA aut Wang Xihai Biological Monitoring and Modeling, Pacific Northwest National Laboratory, 99354, Richland, WA, USA aut Sowa Marianne Cell Biology and Biochemistry, Pacific Northwest National Laboratory, 99354, Richland, WA, USA aut Radiation and Environmental Biophysics Springer-Verlag 50/3(2011-08-01), 365-369 0301-634X 50:3<365 2011 50 411 https://doi.org/10.1007/s00411-011-0371-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00411-011-0371-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Miller John School of Electrical Engineering and Computer Science, Washington State University Tri-Cities, 2710 University Drive, 99354, Richland, WA, USA aut NATIONALLICENCE 700 1- Chrisler William Cell Biology and Biochemistry, Pacific Northwest National Laboratory, 99354, Richland, WA, USA aut NATIONALLICENCE 700 1- Wang Xihai Biological Monitoring and Modeling, Pacific Northwest National Laboratory, 99354, Richland, WA, USA aut NATIONALLICENCE 700 1- Sowa Marianne Cell Biology and Biochemistry, Pacific Northwest National Laboratory, 99354, Richland, WA, USA aut NATIONALLICENCE 773 0- Radiation and Environmental Biophysics Springer-Verlag 50/3(2011-08-01), 365-369 0301-634X 50:3<365 2011 50 411 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer