caa a22 4500 445812974 CHVBK 20180317145217.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00411-011-0363-z doi (NATIONALLICENCE)springer-10.1007/s00411-011-0363-z Does the cortical bone resorption rate change due to 90Sr-radiation exposure? Analysis of data from Techa Riverside residents [Elektronische Daten] [Evgenia Tolstykh, Natalia Shagina, Marina Degteva, Lynn Anspaugh, Bruce Napier] The Mayak Production Association released large amounts of 90Sr into the Techa River (Southern Urals, Russia) with peak amounts in 1950-1951. Techa Riverside residents ingested an average of about 3,000kBq of 90Sr. The 90Sr-body burden of approximately 15,000 individuals has been measured in the Urals Research Center for Radiation Medicine in 1974-1997 with use of a special whole-body counter (WBC). Strontium-90 had mainly deposited in the cortical part of the skeleton by 25years following intake, and 90Sr elimination occurs as a result of cortical bone resorption. The effect of 90Sr-radiation exposure on the rate of cortical bone resorption was studied. Data on 2,022 WBC measurements were selected for 207 adult persons, who were measured three or more times before they were 50-55years old. The individual-resorption rates were calculated with the rate of strontium recirculation evaluated as 0.0018year−1. Individual absorbed doses in red bone marrow (RBM) and bone surface (BS) were also calculated. Statistically significant negative relationships of cortical bone resorption rate were discovered related to 90Sr-body burden and dose absorbed in the RBM or the BS. The response appears to have a threshold of about 1.5-Gy RBM dose. The radiation-induced decrease in bone resorption rate may not be significant in terms of health. However, a decrease in bone remodeling rate can be among several causes of an increased level of degenerative dystrophic bone pathology in exposed persons. Springer-Verlag, 2011 Tolstykh Evgenia Urals Research Center for Radiation Medicine, Vorovskogo 68a, 454076, Chelyabinsk, Russian Federation aut Shagina Natalia Urals Research Center for Radiation Medicine, Vorovskogo 68a, 454076, Chelyabinsk, Russian Federation aut Degteva Marina Urals Research Center for Radiation Medicine, Vorovskogo 68a, 454076, Chelyabinsk, Russian Federation aut Anspaugh Lynn Radiobiology Division, Department of Radiology, University of Utah, Salt Lake City, UT, USA aut Napier Bruce Pacific Northwest National Laboratory, Richland, WA, USA aut Radiation and Environmental Biophysics Springer-Verlag 50/3(2011-08-01), 417-430 0301-634X 50:3<417 2011 50 411 https://doi.org/10.1007/s00411-011-0363-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00411-011-0363-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tolstykh Evgenia Urals Research Center for Radiation Medicine, Vorovskogo 68a, 454076, Chelyabinsk, Russian Federation aut NATIONALLICENCE 700 1- Shagina Natalia Urals Research Center for Radiation Medicine, Vorovskogo 68a, 454076, Chelyabinsk, Russian Federation aut NATIONALLICENCE 700 1- Degteva Marina Urals Research Center for Radiation Medicine, Vorovskogo 68a, 454076, Chelyabinsk, Russian Federation aut NATIONALLICENCE 700 1- Anspaugh Lynn Radiobiology Division, Department of Radiology, University of Utah, Salt Lake City, UT, USA aut NATIONALLICENCE 700 1- Napier Bruce Pacific Northwest National Laboratory, Richland, WA, USA aut NATIONALLICENCE 773 0- Radiation and Environmental Biophysics Springer-Verlag 50/3(2011-08-01), 417-430 0301-634X 50:3<417 2011 50 411 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer