caa a22 4500 445813059 CHVBK 20180317145218.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00411-011-0380-y doi (NATIONALLICENCE)springer-10.1007/s00411-011-0380-y Mutagenicity of diagnostic and therapeutical doses of radiopharmaceutical iodine-131 in Wistar rats [Elektronische Daten] [Elisângela Düsman, Alessandra Berti, Rosinete Mariucci, Nilson Lopes, Veronica Vicentini] Iodine-131 (131I) is a radioisotope used for the diagnosis and treatment of thyroidal disorders such as hyperthyroidism and cancer. During its decay, 131I emits beta particles and gamma rays; its physical half-life is 8days, and it is accumulated preferentially in the thyroid tissue. This study aimed to evaluate the cytotoxicity and mutagenicity of diagnostic and therapeutic doses of 131I using bone marrow cells of rats treated in vivo in a test system with a single dose by gavage. Concentrations of 5, 25, 50 and 250μCi in 1ml of water were used, and after 24h, the animals were killed. Also, a concentration of 25μCi/ml of water was used, and the animals were killed after 5days. The results showed that no concentration of 131I was cytotoxic and that all concentrations were mutagenic. As a result, there was no statistically significant difference detected by the χ2 test in the induction of chromosomal aberrations between the different doses. Thus, the present study demonstrated a significant increase in chromosomal aberration in bone marrow cells exposed to 131I regardless of the dose or the treatment time. Springer-Verlag, 2011 Düsman Elisângela Department of Cell Biology and Genetics, State University of Maringá, Avenida Colombo 5790, Bloco H67 (11), Jardim Universitário, CEP 87020-900, Maringá, Paraná, Brazil aut Berti Alessandra Department of Cell Biology and Genetics, State University of Maringá, Avenida Colombo 5790, Bloco H67 (11), Jardim Universitário, CEP 87020-900, Maringá, Paraná, Brazil aut Mariucci Rosinete Department of Cell Biology and Genetics, State University of Maringá, Avenida Colombo 5790, Bloco H67 (11), Jardim Universitário, CEP 87020-900, Maringá, Paraná, Brazil aut Lopes Nilson Department of Physics, State University of Maringá, Avenida Colombo 5790, Jardim Universitário, CEP 87020-900, Maringá, Paraná, Brazil aut Vicentini Veronica Department of Cell Biology and Genetics, State University of Maringá, Avenida Colombo 5790, Bloco H67 (11), Jardim Universitário, CEP 87020-900, Maringá, Paraná, Brazil aut Radiation and Environmental Biophysics Springer-Verlag 50/4(2011-11-01), 579-584 0301-634X 50:4<579 2011 50 411 https://doi.org/10.1007/s00411-011-0380-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00411-011-0380-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Düsman Elisângela Department of Cell Biology and Genetics, State University of Maringá, Avenida Colombo 5790, Bloco H67 (11), Jardim Universitário, CEP 87020-900, Maringá, Paraná, Brazil aut NATIONALLICENCE 700 1- Berti Alessandra Department of Cell Biology and Genetics, State University of Maringá, Avenida Colombo 5790, Bloco H67 (11), Jardim Universitário, CEP 87020-900, Maringá, Paraná, Brazil aut NATIONALLICENCE 700 1- Mariucci Rosinete Department of Cell Biology and Genetics, State University of Maringá, Avenida Colombo 5790, Bloco H67 (11), Jardim Universitário, CEP 87020-900, Maringá, Paraná, Brazil aut NATIONALLICENCE 700 1- Lopes Nilson Department of Physics, State University of Maringá, Avenida Colombo 5790, Jardim Universitário, CEP 87020-900, Maringá, Paraná, Brazil aut NATIONALLICENCE 700 1- Vicentini Veronica Department of Cell Biology and Genetics, State University of Maringá, Avenida Colombo 5790, Bloco H67 (11), Jardim Universitário, CEP 87020-900, Maringá, Paraná, Brazil aut NATIONALLICENCE 773 0- Radiation and Environmental Biophysics Springer-Verlag 50/4(2011-11-01), 579-584 0301-634X 50:4<579 2011 50 411 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer