caa a22 4500 445813067 CHVBK 20180317145218.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00411-011-0386-5 doi (NATIONALLICENCE)springer-10.1007/s00411-011-0386-5 The role of miRNA in the direct and indirect effects of ionizing radiation [Elektronische Daten] [Jennifer Dickey, Franz Zemp, Olga Martin, Olga Kovalchuk] This review focuses on a number of recent studies that have examined changes in microRNA (miRNA) expression profiles in response to ionizing radiation and other forms of oxidative stress. In both murine and human cells and tissues, a number of miRNAs display significant alterations in expression levels in response to both direct and indirect radiation exposure. In terms of direct irradiation, or exposure to agents that induce oxidative stress, miRNA array analyses indicate that a number of miRNAs are up- and down-regulated and, in particular, the let-7 family of miRNAs may well be critical in the cellular response to oxidative stress. In bystander cells that are not directly irradiated, but close to, or share media with directly irradiated cells or tissues, the miRNA expression profiles are also altered, but are somewhat distinct from the directly irradiated cells. Based on the results of these numerous studies, as well as our own data presented here, we conclude that miRNA regulation is a critical step in the cellular response to radiation and oxidative stress and that future studies should elucidate the mechanisms through which this altered regulation affects cell metabolism. Springer-Verlag, 2011 Dickey Jennifer Laboratory of Biochemistry, Division of Therapeutic Proteins, CDER, FDA, 29 Lincoln Drive, Bldg 29A, Room 2B-24, 20892, Bethesda, MD, USA aut Zemp Franz Department of Biological Sciences, University of Lethbridge, 4401 University Drive, T1K 3M4, Lethbridge, AB, Canada aut Martin Olga Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, NIH, 9000 Rockville Pike, 20892, Bethesda, MD, USA aut Kovalchuk Olga Department of Biological Sciences, University of Lethbridge, 4401 University Drive, T1K 3M4, Lethbridge, AB, Canada aut Radiation and Environmental Biophysics Springer-Verlag 50/4(2011-11-01), 491-499 0301-634X 50:4<491 2011 50 411 https://doi.org/10.1007/s00411-011-0386-5 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00411-011-0386-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dickey Jennifer Laboratory of Biochemistry, Division of Therapeutic Proteins, CDER, FDA, 29 Lincoln Drive, Bldg 29A, Room 2B-24, 20892, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Zemp Franz Department of Biological Sciences, University of Lethbridge, 4401 University Drive, T1K 3M4, Lethbridge, AB, Canada aut NATIONALLICENCE 700 1- Martin Olga Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, NIH, 9000 Rockville Pike, 20892, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Kovalchuk Olga Department of Biological Sciences, University of Lethbridge, 4401 University Drive, T1K 3M4, Lethbridge, AB, Canada aut NATIONALLICENCE 773 0- Radiation and Environmental Biophysics Springer-Verlag 50/4(2011-11-01), 491-499 0301-634X 50:4<491 2011 50 411 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer