caa a22 4500 445813121 CHVBK 20180317145218.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00411-010-0350-9 doi (NATIONALLICENCE)springer-10.1007/s00411-010-0350-9 Maternal occupational exposure to ionizing radiation and birth defects [Elektronische Daten] [Awi Wiesel, Claudia Spix, Andreas Mergenthaler, Annette Queißer-Luft] So far, only a few studies investigated occupational exposure to ionizing radiation in pregnancy to cause birth defects (BDs). No association between BDs and ionizing radiation, although described for high-dose exposure, could ever be confirmed for employees, or specific job titles. Here, an explorative analysis of a prospective population-based birth cohort used to quantify the prevalence of BDs in infants between 1/2007 and 2/2008 is presented. An active examination of all livebirths by specially trained paediatricians in two defined areas was performed. Additionally, a study-specific questionnaire distributed among all becoming mothers in the surveyed regions included questions on maternal occupational exposure to ionizing radiation within the first trimester of pregnancy. In 3,816 births (including 165 infants with BDs; 4.3%), maternal answers concerning possible exposures to medical and occupational ionizing radiation were available. Relative risk (RR) estimates in mothers surveyed for occupational exposure to ionizing radiation (wearing a radiation dosimeter) and BDs in the offspring were calculated exploratively. A higher prevalence of infants with BDs (n=4; 13.8%) was documented in newborns of the 29 surveyed mothers compared to that in 3,787 births from unexposed mothers (n=161; 4.3%), corresponding to a RR of 3.2 (1.2-8.7). Excluding deformations, the RR increased to 4.0 (1.5-10.7). Adjustment for possible confounders did not change the results substantially. Springer-Verlag, 2011 Wiesel Awi Birth Registry Mainz Model, Children's Hospital, University Medical Center of the Johannes Gutenberg University, Langenbeckstr.1, 55131, Mainz, Germany aut Spix Claudia Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany aut Mergenthaler Andreas Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany aut Queißer-Luft Annette Birth Registry Mainz Model, Children's Hospital, University Medical Center of the Johannes Gutenberg University, Langenbeckstr.1, 55131, Mainz, Germany aut Radiation and Environmental Biophysics Springer-Verlag 50/2(2011-05-01), 325-328 0301-634X 50:2<325 2011 50 411 https://doi.org/10.1007/s00411-010-0350-9 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00411-010-0350-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wiesel Awi Birth Registry Mainz Model, Children's Hospital, University Medical Center of the Johannes Gutenberg University, Langenbeckstr.1, 55131, Mainz, Germany aut NATIONALLICENCE 700 1- Spix Claudia Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany aut NATIONALLICENCE 700 1- Mergenthaler Andreas Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany aut NATIONALLICENCE 700 1- Queißer-Luft Annette Birth Registry Mainz Model, Children's Hospital, University Medical Center of the Johannes Gutenberg University, Langenbeckstr.1, 55131, Mainz, Germany aut NATIONALLICENCE 773 0- Radiation and Environmental Biophysics Springer-Verlag 50/2(2011-05-01), 325-328 0301-634X 50:2<325 2011 50 411 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer