caa a22 4500 445813164 CHVBK 20180317145218.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00411-011-0351-3 doi (NATIONALLICENCE)springer-10.1007/s00411-011-0351-3 Modeling hematopoietic system response caused by chronic exposure to ionizing radiation [Elektronische Daten] [Igor Akushevich, Galina Veremeyeva, Georgy Dimov, Svetlana Ukraintseva, Konstantin Arbeev, Alexander Akleyev, Anatoly Yashin] A new model of the hematopoietic system response in humans chronically exposed to ionizing radiation describes the dynamics of the hematopoietic stem cell compartment as well as the dynamics of each of the four blood cell types (lymphocytes, neutrophiles, erythrocytes, and platelets). The required model parameters were estimated based on available results of human and experimental animal studies. They include the steady-state number of hematopoietic stem cells and peripheral blood cell lines in an unexposed organism, amplification parameters for each blood line, parameters describing proliferation and apoptosis, parameters of feedback functions regulating the steady-state numbers, and characteristics of radiosensitivity related to cell death and non-lethal cell damage. The model predictions were tested using data on hematological measurements (e.g., blood counts) performed in 1950-1956 in the Techa River residents chronically exposed to ionizing radiation since 1949. The suggested model of hematopoiesis is capable of describing experimental findings in the Techa River Cohort, including: (1) slopes of the dose-effect curves reflecting the inhibition of hematopoiesis due to chronic ionizing radiation, (2) delay in effect of chronic exposure and accumulated character of the effect, and (3) dose-rate patterns for different cytopenic states (e.g., leukopenia, thrombocytopenia). Springer-Verlag, 2011 Akushevich Igor Center for Population Health and Aging, Duke University, 002 Trent Hall, Box 90408, 27708-0408, Durham, NC, USA aut Veremeyeva Galina Urals Research Center for Radiation Medicine, Chelyabinsk, Russia aut Dimov Georgy Urals Research Center for Radiation Medicine, Chelyabinsk, Russia aut Ukraintseva Svetlana Center for Population Health and Aging, Duke University, 002 Trent Hall, Box 90408, 27708-0408, Durham, NC, USA aut Arbeev Konstantin Center for Population Health and Aging, Duke University, 002 Trent Hall, Box 90408, 27708-0408, Durham, NC, USA aut Akleyev Alexander Urals Research Center for Radiation Medicine, Chelyabinsk, Russia aut Yashin Anatoly Center for Population Health and Aging, Duke University, 002 Trent Hall, Box 90408, 27708-0408, Durham, NC, USA aut Radiation and Environmental Biophysics Springer-Verlag 50/2(2011-05-01), 299-311 0301-634X 50:2<299 2011 50 411 https://doi.org/10.1007/s00411-011-0351-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00411-011-0351-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Akushevich Igor Center for Population Health and Aging, Duke University, 002 Trent Hall, Box 90408, 27708-0408, Durham, NC, USA aut NATIONALLICENCE 700 1- Veremeyeva Galina Urals Research Center for Radiation Medicine, Chelyabinsk, Russia aut NATIONALLICENCE 700 1- Dimov Georgy Urals Research Center for Radiation Medicine, Chelyabinsk, Russia aut NATIONALLICENCE 700 1- Ukraintseva Svetlana Center for Population Health and Aging, Duke University, 002 Trent Hall, Box 90408, 27708-0408, Durham, NC, USA aut NATIONALLICENCE 700 1- Arbeev Konstantin Center for Population Health and Aging, Duke University, 002 Trent Hall, Box 90408, 27708-0408, Durham, NC, USA aut NATIONALLICENCE 700 1- Akleyev Alexander Urals Research Center for Radiation Medicine, Chelyabinsk, Russia aut NATIONALLICENCE 700 1- Yashin Anatoly Center for Population Health and Aging, Duke University, 002 Trent Hall, Box 90408, 27708-0408, Durham, NC, USA aut NATIONALLICENCE 773 0- Radiation and Environmental Biophysics Springer-Verlag 50/2(2011-05-01), 299-311 0301-634X 50:2<299 2011 50 411 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer