caa a22 4500 445813172 CHVBK 20180317145218.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00411-011-0357-x doi (NATIONALLICENCE)springer-10.1007/s00411-011-0357-x Effect of site-specific bronchial radon progeny deposition on the spatial and temporal distributions of cellular responses [Elektronische Daten] [Árpád Farkas, Werner Hofmann, Imre Balásházy, István Szőke, Balázs Madas, Mona Moustafa] Inhaled short-lived radon progenies may deposit in bronchial airways and interact with the epithelium by the emission of alpha particles. Simulation of the related radiobiological effects requires the knowledge of space and time distributions of alpha particle hits and biological endpoints. Present modelling efforts include simulation of radioaerosol deposition patterns in a central bronchial airway bifurcation, modelling of human bronchial epithelium, generation of alpha particle tracks, and computation of spatio-temporal distributions of cell nucleus hits, cell killing and cell transformation events. Simulation results indicate that the preferential radionuclide deposition at carinal ridges plays an important role in the space and time evolution of the biological events. While multiple hits are generally rare for low cumulative exposures, their probability may be quite high at the carinal ridges of the airway bifurcations. Likewise, cell killing and transformation events also occur with higher probability in this area. In the case of uniform surface activities, successive hits as well as cell killing and transformation events within a restricted area (say 0.5mm2) are well separated in time. However, in the case of realistic inhomogeneous deposition, they occur more frequently within the mean cycle time of cells located at the carinal ridge even at low cumulative doses. The site-specificity of radionuclide deposition impacts not only on direct, but also on non-targeted radiobiological effects due to intercellular communication. Incorporation of present results into mechanistic models of carcinogenesis may provide useful information concerning the dose-effect relationship in the low-dose range. Springer-Verlag, 2011 Farkas Árpád Health and Environmental Physics Department, Hungarian Academy of Sciences KFKI Atomic Energy Research Institute, Konkoly Thege M. út 29-33, 1121, Budapest, Hungary aut Hofmann Werner Division of Physics and Biophysics, Department of Materials Research and Physics, University of Salzburg, Hellbrunner Str. 34, 5020, Salzburg, Austria aut Balásházy Imre Health and Environmental Physics Department, Hungarian Academy of Sciences KFKI Atomic Energy Research Institute, Konkoly Thege M. út 29-33, 1121, Budapest, Hungary aut Szőke István Health and Environmental Physics Department, Hungarian Academy of Sciences KFKI Atomic Energy Research Institute, Konkoly Thege M. út 29-33, 1121, Budapest, Hungary aut Madas Balázs Health and Environmental Physics Department, Hungarian Academy of Sciences KFKI Atomic Energy Research Institute, Konkoly Thege M. út 29-33, 1121, Budapest, Hungary aut Moustafa Mona Physics Department, Faculty of Science, Minia University, Minia, Egypt aut Radiation and Environmental Biophysics Springer-Verlag 50/2(2011-05-01), 281-297 0301-634X 50:2<281 2011 50 411 https://doi.org/10.1007/s00411-011-0357-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00411-011-0357-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Farkas Árpád Health and Environmental Physics Department, Hungarian Academy of Sciences KFKI Atomic Energy Research Institute, Konkoly Thege M. út 29-33, 1121, Budapest, Hungary aut NATIONALLICENCE 700 1- Hofmann Werner Division of Physics and Biophysics, Department of Materials Research and Physics, University of Salzburg, Hellbrunner Str. 34, 5020, Salzburg, Austria aut NATIONALLICENCE 700 1- Balásházy Imre Health and Environmental Physics Department, Hungarian Academy of Sciences KFKI Atomic Energy Research Institute, Konkoly Thege M. út 29-33, 1121, Budapest, Hungary aut NATIONALLICENCE 700 1- Szőke István Health and Environmental Physics Department, Hungarian Academy of Sciences KFKI Atomic Energy Research Institute, Konkoly Thege M. út 29-33, 1121, Budapest, Hungary aut NATIONALLICENCE 700 1- Madas Balázs Health and Environmental Physics Department, Hungarian Academy of Sciences KFKI Atomic Energy Research Institute, Konkoly Thege M. út 29-33, 1121, Budapest, Hungary aut NATIONALLICENCE 700 1- Moustafa Mona Physics Department, Faculty of Science, Minia University, Minia, Egypt aut NATIONALLICENCE 773 0- Radiation and Environmental Biophysics Springer-Verlag 50/2(2011-05-01), 281-297 0301-634X 50:2<281 2011 50 411 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer