caa a22 4500 445813180 CHVBK 20180317145218.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00411-011-0354-0 doi (NATIONALLICENCE)springer-10.1007/s00411-011-0354-0 Radiation-induced cell cycle arrests in Ehrlich ascites carcinoma cells in vivo [Elektronische Daten] [S. Tokalov, A. Iagunov] Radiation-induced progression delay in G1/S, S and G2/M phases of p53 wild-type Ehrlich ascites carcinoma (EAC) cells growing in vivo was investigated by DNA flow cytometry. Different behavior patterns of EAC cells at the time after irradiation with low (2, 4, 6, 8Gy) and high (10, 15, 20Gy) doses were evaluated. While EAC cells showed a small progression delay in S phase and a dose-dependent block in G2/M phase after the irradiation with low doses, a clear additional block in G1/S phase was observed after irradiation with high doses. An assessment of the damage response and repair networks at the time after irradiation might have important implication for the development of cancer management and treatment. Springer-Verlag, 2011 Tokalov S. Medical Faculty Carl Gustav Carus, OncoRay—Center for Radiation Research in Oncology, Dresden University of Technology, Fetscherstraße 74, P.O. Box 86, 01307, Dresden, Germany aut Iagunov A. Research Laboratory of the Late Radiation Pathology, The Russian Center for Research in Radiological and Surgical Techniques, 199646, St. Petersburg, Russia aut Radiation and Environmental Biophysics Springer-Verlag 50/2(2011-05-01), 265-270 0301-634X 50:2<265 2011 50 411 https://doi.org/10.1007/s00411-011-0354-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00411-011-0354-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tokalov S. Medical Faculty Carl Gustav Carus, OncoRay—Center for Radiation Research in Oncology, Dresden University of Technology, Fetscherstraße 74, P.O. Box 86, 01307, Dresden, Germany aut NATIONALLICENCE 700 1- Iagunov A. Research Laboratory of the Late Radiation Pathology, The Russian Center for Research in Radiological and Surgical Techniques, 199646, St. Petersburg, Russia aut NATIONALLICENCE 773 0- Radiation and Environmental Biophysics Springer-Verlag 50/2(2011-05-01), 265-270 0301-634X 50:2<265 2011 50 411 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer