caa a22 4500 445813199 CHVBK 20180317145218.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00411-010-0349-2 doi (NATIONALLICENCE)springer-10.1007/s00411-010-0349-2 Birth defects in the vicinity of nuclear power plants in Germany [Elektronische Daten] [Annette Queißer-Luft, Awi Wiesel, Gabriela Stolz, Andreas Mergenthaler, Melanie Kaiser, Klaus Schlaefer, Jürgen Wahrendorf, Maria Blettner, Claudia Spix] Living in the vicinity of nuclear power plants (NPP) is discussed here in terms of adverse health effects. A prospective population-based cohort study was conducted to evaluate whether the prevalence of birth defects in the vicinity of NPPs is elevated and scrutinize a possible distance correlation. A birth cohort born to mothers living within 10km of two selected NPPs (study region) was compared to a region without NPP (comparison region), and an active surveillance of all live births, stillbirths, and induced abortions in the defined regions was performed. Between 01/2007 and 02/2008, all newborns were examined by specially trained study paediatricians according to the protocols of the Birth Registry Mainz Model. The cohort consisted of 5,273 infants (90% completeness). The outcome measure was an infant with birth defect(s). The prevalence of infants with birth defects was 4.5% in the study region and 4.7% in the comparison region, which corresponds to a relative risk (RR) of 0.94 (lower 95% confidence level (CL): 0.76). Thus, the prevalence of birth defects in the regions surrounding NPPs was not increased compared to those of the comparison region. Adjustment for potential confounders did not substantially change the result (RR 0.90, lower 95% CL 0.73). The adjusted and unadjusted distance approach (1/distance in km) did not show any correlation to vicinity to a NPP (p=0.38). Specifically, within the study region, the prevalence of birth defects showed no upward trend with decreasing distance. Birth defect prevalence and most descriptive parameters in the comparison region were identical to those in the Birth Registry Mainz Model. Springer-Verlag, 2011 Queißer-Luft Annette Birth Registry Mainz Model, Department of Pediatrics, University Medical Centre of the Johannes Gutenberg University Mainz, Langenbeckstr.1, 55131, Mainz, Germany aut Wiesel Awi Birth Registry Mainz Model, Department of Pediatrics, University Medical Centre of the Johannes Gutenberg University Mainz, Langenbeckstr.1, 55131, Mainz, Germany aut Stolz Gabriela Birth Registry Mainz Model, Department of Pediatrics, University Medical Centre of the Johannes Gutenberg University Mainz, Langenbeckstr.1, 55131, Mainz, Germany aut Mergenthaler Andreas Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Centre of the Johannes Gutenberg University Mainz, Obere Zahlbacher Str. 69, 55131, Mainz, Germany aut Kaiser Melanie Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Centre of the Johannes Gutenberg University Mainz, Obere Zahlbacher Str. 69, 55131, Mainz, Germany aut Schlaefer Klaus Unit of Environmental Epidemiology, German Cancer Research Institute (DKFZ), C030, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut Wahrendorf Jürgen Unit of Environmental Epidemiology, German Cancer Research Institute (DKFZ), C030, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut Blettner Maria Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Centre of the Johannes Gutenberg University Mainz, Obere Zahlbacher Str. 69, 55131, Mainz, Germany aut Spix Claudia Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Centre of the Johannes Gutenberg University Mainz, Obere Zahlbacher Str. 69, 55131, Mainz, Germany aut Radiation and Environmental Biophysics Springer-Verlag 50/2(2011-05-01), 313-323 0301-634X 50:2<313 2011 50 411 https://doi.org/10.1007/s00411-010-0349-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00411-010-0349-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Queißer-Luft Annette Birth Registry Mainz Model, Department of Pediatrics, University Medical Centre of the Johannes Gutenberg University Mainz, Langenbeckstr.1, 55131, Mainz, Germany aut NATIONALLICENCE 700 1- Wiesel Awi Birth Registry Mainz Model, Department of Pediatrics, University Medical Centre of the Johannes Gutenberg University Mainz, Langenbeckstr.1, 55131, Mainz, Germany aut NATIONALLICENCE 700 1- Stolz Gabriela Birth Registry Mainz Model, Department of Pediatrics, University Medical Centre of the Johannes Gutenberg University Mainz, Langenbeckstr.1, 55131, Mainz, Germany aut NATIONALLICENCE 700 1- Mergenthaler Andreas Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Centre of the Johannes Gutenberg University Mainz, Obere Zahlbacher Str. 69, 55131, Mainz, Germany aut NATIONALLICENCE 700 1- Kaiser Melanie Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Centre of the Johannes Gutenberg University Mainz, Obere Zahlbacher Str. 69, 55131, Mainz, Germany aut NATIONALLICENCE 700 1- Schlaefer Klaus Unit of Environmental Epidemiology, German Cancer Research Institute (DKFZ), C030, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut NATIONALLICENCE 700 1- Wahrendorf Jürgen Unit of Environmental Epidemiology, German Cancer Research Institute (DKFZ), C030, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut NATIONALLICENCE 700 1- Blettner Maria Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Centre of the Johannes Gutenberg University Mainz, Obere Zahlbacher Str. 69, 55131, Mainz, Germany aut NATIONALLICENCE 700 1- Spix Claudia Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Centre of the Johannes Gutenberg University Mainz, Obere Zahlbacher Str. 69, 55131, Mainz, Germany aut NATIONALLICENCE 773 0- Radiation and Environmental Biophysics Springer-Verlag 50/2(2011-05-01), 313-323 0301-634X 50:2<313 2011 50 411 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer