caa a22 4500 445816449 CHVBK 20180317145229.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s10815-010-9479-3 doi (NATIONALLICENCE)springer-10.1007/s10815-010-9479-3 The role of hyaluronic acid binding assay in choosing the fertilization method for patients undergoing IVF for unexplained infertility [Elektronische Daten] [Peter Kovacs, Timea Kovats, Attila Sajgo, Janos Szollosi, Szabolcs Matyas, Steven Kaali] Purpose: Patients with unexplained infertility may have fertilization problems. Split fertilization (ICSI and conventional IVF on sibling oocytes) is often used to avoid poor fertilization. Our aim was to assess the ability of hyaluronic acid binding (HA-binding) assay to predict spontaneous fertilization during IVF. Methods: Prospective, blinded, controlled trial. Patients undergoing their first IVF cycle for unexplained infertility were eligible. Split fertilization was used. IVF and ICSI fertilization rates and embryo development based on 3 HA-binding cut-offs (< 60%; 60-80%; >80%) were compared. Results: ICSI fertilization was higher than IVF, but none of the HA-binding cut-off levels predicted those cases where IVF was less effective, therefore ICSI only would have lead to improved outcome. Embryo development and morphology were similar in all cut-off groups. Conclusions: HA-binding did not predict spontaneous fertilization in patients with unexplained infertility undergoing IVF treatment. When it was used for "screening” it did not help to select the method of fertilization. Springer Science+Business Media, LLC, 2010 Hyaluronic acid binding nationallicence Unexplained infertility nationallicence ICSI nationallicence Sibling oocytes nationallicence Fertilization rate nationallicence Kovacs Peter IVF Center, Kaali Institute, Istenhegyi ut 54/a, 1125, Budapest, Hungary aut Kovats Timea IVF Center, Kaali Institute, Istenhegyi ut 54/a, 1125, Budapest, Hungary aut Sajgo Attila IVF Center, Kaali Institute, Istenhegyi ut 54/a, 1125, Budapest, Hungary aut Szollosi Janos Department of Obstetrics and Gynecology, Szegedi Tudomanyegyetem, Szeged, Hungary aut Matyas Szabolcs IVF Center, Kaali Institute, Istenhegyi ut 54/a, 1125, Budapest, Hungary aut Kaali Steven IVF Center, Kaali Institute, Istenhegyi ut 54/a, 1125, Budapest, Hungary aut Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/1(2011-01-01), 49-54 1058-0468 28:1<49 2011 28 10815 https://doi.org/10.1007/s10815-010-9479-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10815-010-9479-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kovacs Peter IVF Center, Kaali Institute, Istenhegyi ut 54/a, 1125, Budapest, Hungary aut NATIONALLICENCE 700 1- Kovats Timea IVF Center, Kaali Institute, Istenhegyi ut 54/a, 1125, Budapest, Hungary aut NATIONALLICENCE 700 1- Sajgo Attila IVF Center, Kaali Institute, Istenhegyi ut 54/a, 1125, Budapest, Hungary aut NATIONALLICENCE 700 1- Szollosi Janos Department of Obstetrics and Gynecology, Szegedi Tudomanyegyetem, Szeged, Hungary aut NATIONALLICENCE 700 1- Matyas Szabolcs IVF Center, Kaali Institute, Istenhegyi ut 54/a, 1125, Budapest, Hungary aut NATIONALLICENCE 700 1- Kaali Steven IVF Center, Kaali Institute, Istenhegyi ut 54/a, 1125, Budapest, Hungary aut NATIONALLICENCE 773 0- Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/1(2011-01-01), 49-54 1058-0468 28:1<49 2011 28 10815 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer