caa a22 4500 445816511 CHVBK 20180317145230.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s10815-010-9485-5 doi (NATIONALLICENCE)springer-10.1007/s10815-010-9485-5 Association between genetic polymorphisms in androgen receptor gene and the risk of preeclampsia in Korean women [Elektronische Daten] [Ji Lim, ShinYoung Kim, Si Lee, So Park, Jung Han, Jin Chung, Moon Kim, Jae Yang, Hyun Ryu] Purpose: To investigate associations between the androgen receptor (AR) polymorphisms as CAG repeats, GGC repeats and c.211G>A polymorphism and the risk of preeclampsia. Methods: The AR polymorphisms were experienced in 184 preeclamptic patients and 190 normal pregnancies and analyzed by multiple logistic regression. Results: Women with GGC repeats>16 were more frequently observed in preeclampsia, compared to those with GGC repeats≤16 [adjOR (95% CI): 3.64 (1.71-6.23)]. However, no significant differences were observed between the two groups with respect to CAG repeats. The genotypic and allelic frequencies of c.211G>A variant were significantly higher in cases than in controls (P < 0.05 for both). In the combined distribution of these polymorphisms, the highest risk of preeclampsia was found among women with the haplotype as CAG > 20/GA/GGC>16 [adjOR (95% CI): 4.26 (1.92-12.23)]. Conclusions: Our findings suggest that longer GGC repeats and c.211G>A variant in the AR gene are associated with increased susceptibility to the risk of preeclampsia. Springer Science+Business Media, LLC, 2010 Androgen receptor nationallicence CAG repeats nationallicence GGC repeats nationallicence c.211G>A polymorphism nationallicence Preeclampsia nationallicence Lim Ji The Laboratory of Medical Genetics, Medical Research Institute, Cheil General Hospital and Women's Healthcare Center, Seoul, South Korea aut Kim ShinYoung The Laboratory of Medical Genetics, Medical Research Institute, Cheil General Hospital and Women's Healthcare Center, Seoul, South Korea aut Lee Si Department of Obstetrics and Gynecology, Cheil General Hospital & Women's Healthcare Center, KwanDong University School of Medicine, 1-19 Mookjung-dong, Jung-gu, 100-380, Seoul, South Korea aut Park So The Laboratory of Medical Genetics, Medical Research Institute, Cheil General Hospital and Women's Healthcare Center, Seoul, South Korea aut Han Jung Department of Obstetrics and Gynecology, Cheil General Hospital & Women's Healthcare Center, KwanDong University School of Medicine, 1-19 Mookjung-dong, Jung-gu, 100-380, Seoul, South Korea aut Chung Jin Department of Obstetrics and Gynecology, Cheil General Hospital & Women's Healthcare Center, KwanDong University School of Medicine, 1-19 Mookjung-dong, Jung-gu, 100-380, Seoul, South Korea aut Kim Moon Department of Obstetrics and Gynecology, Cheil General Hospital & Women's Healthcare Center, KwanDong University School of Medicine, 1-19 Mookjung-dong, Jung-gu, 100-380, Seoul, South Korea aut Yang Jae Department of Obstetrics and Gynecology, Cheil General Hospital & Women's Healthcare Center, KwanDong University School of Medicine, 1-19 Mookjung-dong, Jung-gu, 100-380, Seoul, South Korea aut Ryu Hyun The Laboratory of Medical Genetics, Medical Research Institute, Cheil General Hospital and Women's Healthcare Center, Seoul, South Korea aut Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/1(2011-01-01), 85-90 1058-0468 28:1<85 2011 28 10815 https://doi.org/10.1007/s10815-010-9485-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10815-010-9485-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lim Ji The Laboratory of Medical Genetics, Medical Research Institute, Cheil General Hospital and Women's Healthcare Center, Seoul, South Korea aut NATIONALLICENCE 700 1- Kim ShinYoung The Laboratory of Medical Genetics, Medical Research Institute, Cheil General Hospital and Women's Healthcare Center, Seoul, South Korea aut NATIONALLICENCE 700 1- Lee Si Department of Obstetrics and Gynecology, Cheil General Hospital & Women's Healthcare Center, KwanDong University School of Medicine, 1-19 Mookjung-dong, Jung-gu, 100-380, Seoul, South Korea aut NATIONALLICENCE 700 1- Park So The Laboratory of Medical Genetics, Medical Research Institute, Cheil General Hospital and Women's Healthcare Center, Seoul, South Korea aut NATIONALLICENCE 700 1- Han Jung Department of Obstetrics and Gynecology, Cheil General Hospital & Women's Healthcare Center, KwanDong University School of Medicine, 1-19 Mookjung-dong, Jung-gu, 100-380, Seoul, South Korea aut NATIONALLICENCE 700 1- Chung Jin Department of Obstetrics and Gynecology, Cheil General Hospital & Women's Healthcare Center, KwanDong University School of Medicine, 1-19 Mookjung-dong, Jung-gu, 100-380, Seoul, South Korea aut NATIONALLICENCE 700 1- Kim Moon Department of Obstetrics and Gynecology, Cheil General Hospital & Women's Healthcare Center, KwanDong University School of Medicine, 1-19 Mookjung-dong, Jung-gu, 100-380, Seoul, South Korea aut NATIONALLICENCE 700 1- Yang Jae Department of Obstetrics and Gynecology, Cheil General Hospital & Women's Healthcare Center, KwanDong University School of Medicine, 1-19 Mookjung-dong, Jung-gu, 100-380, Seoul, South Korea aut NATIONALLICENCE 700 1- Ryu Hyun The Laboratory of Medical Genetics, Medical Research Institute, Cheil General Hospital and Women's Healthcare Center, Seoul, South Korea aut NATIONALLICENCE 773 0- Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/1(2011-01-01), 85-90 1058-0468 28:1<85 2011 28 10815 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer