caa a22 4500 445816538 CHVBK 20180317145230.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s10815-010-9478-4 doi (NATIONALLICENCE)springer-10.1007/s10815-010-9478-4 A new hypothesis regarding ovarian follicle development: ovarian rigidity as a regulator of selection and health [Elektronische Daten] [Teresa Woodruff, Lonnie Shea] The mammalian ovary consists of a large number of dormant immature follicles, each containing a single oocyte and located on the periphery of the ovary. With each reproductive cycle, a group of immature follicles is sequentially activated to resume growth, and pituitary gonadotropins and ovarian steroid and peptide hormones cooperate to ensure further growth and development. A single dominant follicle eventually emerges, ovulates, and then involutes to allow the selection of the next group of follicles. While hormones are known to control the later stages of folliculogenesis, little is known about the pathways that activate individual immature primordial follicles in the dormant follicle pool. We advance a new hypothesis: that follicle activation is dependent on the physical environment of the ovary in addition to well-established hormonal cues. This novel perspective on ovarian function may provide new avenues to study follicle dynamics and identify therapeutic targets for ovarian dysfunction. Springer Science+Business Media, LLC, 2010 Ovary nationallicence Follicle nationallicence Endocrine nationallicence Alginate nationallicence Biomaterials nationallicence Woodruff Teresa Center for Reproductive Research, Northwestern University, 2205 Tech Drive, Hogan 2-160, 60208, Evanston, IL, USA aut Shea Lonnie Center for Reproductive Research, Northwestern University, 2205 Tech Drive, Hogan 2-160, 60208, Evanston, IL, USA aut Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/1(2011-01-01), 3-6 1058-0468 28:1<3 2011 28 10815 https://doi.org/10.1007/s10815-010-9478-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10815-010-9478-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Woodruff Teresa Center for Reproductive Research, Northwestern University, 2205 Tech Drive, Hogan 2-160, 60208, Evanston, IL, USA aut NATIONALLICENCE 700 1- Shea Lonnie Center for Reproductive Research, Northwestern University, 2205 Tech Drive, Hogan 2-160, 60208, Evanston, IL, USA aut NATIONALLICENCE 773 0- Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/1(2011-01-01), 3-6 1058-0468 28:1<3 2011 28 10815 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer